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<meta content="Chuah, Meng Inn" name="eprints.creators_name" />
<meta content="Choi-Lundberg, D.L." name="eprints.creators_name" />
<meta content="Weston, S." name="eprints.creators_name" />
<meta content="Vincent, A.J." name="eprints.creators_name" />
<meta content="Chung, R.S." name="eprints.creators_name" />
<meta content="Vickers, J.C." name="eprints.creators_name" />
<meta content="West, A.K." name="eprints.creators_name" />
<meta content="Inn.Chuah@utas.edu.au" name="eprints.creators_id" />
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<meta content="Olfactory ensheathing cells promote collateral axonal branching in the injured adult rat spinal cord" name="eprints.title" />
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<meta content="Olfactory ensheathing cells; Spinal cord; Regeneration; Corticospinal tract; Collateral sprouting" name="eprints.keywords" />
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<meta content="In recent years, injection of olfactory ensheathing cells (ECs) into the spinal cord has been used as an experimental strategy to promote
regeneration of injured axons. In this study, we have compared the effects of transplanting encapsulated ECs with those injected directly into
the spinal cord. The dorsal columns of adult rats were cut at T8–9 and rats in experimental groups received either EC-filled porous polymer
capsules or culture medium (CM)-filled capsules with ECs injected at the injury site. Control rats were in three groups: (1) uninjured, (2)
lesion with transplantation of CM-filled capsules and (3) lesion with transplantation of CM-filled capsules and injections of CM. Three weeks
after injury, Fluororuby was injected into the hindlimb motor and somatosensory cortex to label corticospinal neurons. Observations indicated
that there were a few regenerating fibres, up to 10, in the EC-treated groups. In rats that received encapsulated ECs, regenerating fibres were
present in close association with the capsule. Rats that received EC injections demonstrated a significant increase in the number of collateral
branches from the intact ventral corticospinal tract (vCST) compared with the corresponding control, CM-injected group ( P = 0.003), while a
trend for increased collateral branches was observed in rats that received encapsulated ECs ( P = 0.07)." name="eprints.abstract" />
<meta content="2004" name="eprints.date" />
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<meta content="Experimental Neurology" name="eprints.publication" />
<meta content="185" name="eprints.volume" />
<meta content="15-25" name="eprints.pagerange" />
<meta content="10.1016/j.expneurol.2003.09.008" name="eprints.id_number" />
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<meta content="0014-4886" name="eprints.issn" />
<meta content="http://dx.doi.org/10.1016/j.expneurol.2003.09.008" name="eprints.official_url" />
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Woodhall, E., West, A.K., Vickers, J.C., Chuah, M.I., 2003. Olfactory
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cord. Cell. Mol. Life Sci. 60, 2241– 2253" name="eprints.referencetext" />
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<meta content="In recent years, injection of olfactory ensheathing cells (ECs) into the spinal cord has been used as an experimental strategy to promote
regeneration of injured axons. In this study, we have compared the effects of transplanting encapsulated ECs with those injected directly into
the spinal cord. The dorsal columns of adult rats were cut at T8–9 and rats in experimental groups received either EC-filled porous polymer
capsules or culture medium (CM)-filled capsules with ECs injected at the injury site. Control rats were in three groups: (1) uninjured, (2)
lesion with transplantation of CM-filled capsules and (3) lesion with transplantation of CM-filled capsules and injections of CM. Three weeks
after injury, Fluororuby was injected into the hindlimb motor and somatosensory cortex to label corticospinal neurons. Observations indicated
that there were a few regenerating fibres, up to 10, in the EC-treated groups. In rats that received encapsulated ECs, regenerating fibres were
present in close association with the capsule. Rats that received EC injections demonstrated a significant increase in the number of collateral
branches from the intact ventral corticospinal tract (vCST) compared with the corresponding control, CM-injected group ( P = 0.003), while a
trend for increased collateral branches was observed in rats that received encapsulated ECs ( P = 0.07)." name="DC.description" />
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<h1 class="ep_tm_pagetitle">Olfactory ensheathing cells promote collateral axonal branching in the injured adult rat spinal cord</h1>
<p style="margin-bottom: 1em" class="not_ep_block"><span class="person_name">Chuah, Meng Inn</span> and <span class="person_name">Choi-Lundberg, D.L.</span> and <span class="person_name">Weston, S.</span> and <span class="person_name">Vincent, A.J.</span> and <span class="person_name">Chung, R.S.</span> and <span class="person_name">Vickers, J.C.</span> and <span class="person_name">West, A.K.</span> (2004) <xhtml:em>Olfactory ensheathing cells promote collateral axonal branching in the injured adult rat spinal cord.</xhtml:em> Experimental Neurology, 185 . pp. 15-25. ISSN 0014-4886</p><p style="margin-bottom: 1em" class="not_ep_block"></p><table style="margin-bottom: 1em" class="not_ep_block"><tr><td valign="top" style="text-align:center"><a href="http://eprints.utas.edu.au/2230/1/chuah_exptlneurol.pdf"><img alt="[img]" src="http://eprints.utas.edu.au/style/images/fileicons/application_pdf.png" class="ep_doc_icon" border="0" /></a></td><td valign="top"><a href="http://eprints.utas.edu.au/2230/1/chuah_exptlneurol.pdf"><span class="ep_document_citation">PDF</span></a> - Full text restricted - Requires a PDF viewer<br />806Kb</td><td><form method="get" accept-charset="utf-8" action="http://eprints.utas.edu.au/cgi/request_doc"><input accept-charset="utf-8" value="2800" name="docid" type="hidden" /><div class=""><input value="Request a copy" name="_action_null" class="ep_form_action_button" onclick="return EPJS_button_pushed( '_action_null' )" type="submit" /> </div></form></td></tr></table><p style="margin-bottom: 1em" class="not_ep_block">Official URL: <a href="http://dx.doi.org/10.1016/j.expneurol.2003.09.008">http://dx.doi.org/10.1016/j.expneurol.2003.09.008</a></p><div class="not_ep_block"><h2>Abstract</h2><p style="padding-bottom: 16px; text-align: left; margin: 1em auto 0em auto">In recent years, injection of olfactory ensheathing cells (ECs) into the spinal cord has been used as an experimental strategy to promote
regeneration of injured axons. In this study, we have compared the effects of transplanting encapsulated ECs with those injected directly into
the spinal cord. The dorsal columns of adult rats were cut at T8–9 and rats in experimental groups received either EC-filled porous polymer
capsules or culture medium (CM)-filled capsules with ECs injected at the injury site. Control rats were in three groups: (1) uninjured, (2)
lesion with transplantation of CM-filled capsules and (3) lesion with transplantation of CM-filled capsules and injections of CM. Three weeks
after injury, Fluororuby was injected into the hindlimb motor and somatosensory cortex to label corticospinal neurons. Observations indicated
that there were a few regenerating fibres, up to 10, in the EC-treated groups. In rats that received encapsulated ECs, regenerating fibres were
present in close association with the capsule. Rats that received EC injections demonstrated a significant increase in the number of collateral
branches from the intact ventral corticospinal tract (vCST) compared with the corresponding control, CM-injected group ( P = 0.003), while a
trend for increased collateral branches was observed in rats that received encapsulated ECs ( P = 0.07).</p></div><table style="margin-bottom: 1em" cellpadding="3" class="not_ep_block" border="0"><tr><th valign="top" class="ep_row">Item Type:</th><td valign="top" class="ep_row">Article</td></tr><tr><th valign="top" class="ep_row">Additional Information:</th><td valign="top" class="ep_row">The definitive version is available at http://www.sciencedirect.com
</td></tr><tr><th valign="top" class="ep_row">Keywords:</th><td valign="top" class="ep_row">Olfactory ensheathing cells; Spinal cord; Regeneration; Corticospinal tract; Collateral sprouting</td></tr><tr><th valign="top" class="ep_row">Subjects:</th><td valign="top" class="ep_row"><a href="http://eprints.utas.edu.au/view/subjects/320000.html">320000 Medical and Health Sciences</a><br /><a href="http://eprints.utas.edu.au/view/subjects/270000.html">270000 Biological Sciences</a></td></tr><tr><th valign="top" class="ep_row">ID Code:</th><td valign="top" class="ep_row">2230</td></tr><tr><th valign="top" class="ep_row">Deposited By:</th><td valign="top" class="ep_row"><span class="ep_name_citation"><span class="person_name">A/Prof MI Chuah</span></span></td></tr><tr><th valign="top" class="ep_row">Deposited On:</th><td valign="top" class="ep_row">17 Oct 2007 16:04</td></tr><tr><th valign="top" class="ep_row">Last Modified:</th><td valign="top" class="ep_row">09 Jan 2008 02:30</td></tr><tr><th valign="top" class="ep_row">ePrint Statistics:</th><td valign="top" class="ep_row"><a target="ePrintStats" href="/es/index.php?action=show_detail_eprint;id=2230;">View statistics for this ePrint</a></td></tr></table><p align="right">Repository Staff Only: <a href="http://eprints.utas.edu.au/cgi/users/home?screen=EPrint::View&eprintid=2230">item control page</a></p>
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