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    <title>UTas ePrints - The tissue factor pathway in ischemic stroke</title>
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    <meta content="Adams, M.J." name="eprints.creators_name" />
<meta content="Thom, J." name="eprints.creators_name" />
<meta content="Hankey, G.J." name="eprints.creators_name" />
<meta content="Baker, Ross I." name="eprints.creators_name" />
<meta content="Gilmore, G." name="eprints.creators_name" />
<meta content="Staton, J.M." name="eprints.creators_name" />
<meta content="Eikelboom, J.W." name="eprints.creators_name" />
<meta content="article" name="eprints.type" />
<meta content="2007-09-27" name="eprints.datestamp" />
<meta content="2008-01-08 15:30:00" name="eprints.lastmod" />
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<meta content="The tissue factor pathway in ischemic stroke" name="eprints.title" />
<meta content="pub" name="eprints.ispublished" />
<meta content="321008" name="eprints.subjects" />
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<meta content="tissue factor, stroke, factor VII, tissue factor pathway inhibitor" name="eprints.keywords" />
<meta content="The definitive version is available online at www.bloodcoagulation.com/" name="eprints.note" />
<meta content="To explore the role of the the tissue factor (TF) pathway in
ischemic stroke. We measured blood concentrations of
markers of the TF pathway [TF antigen, free tissue factor
pathway inhibitor antigen (TFPIf) and activity (TFPIac), and
activated factor VII (FVIIa)] within 7 days (acute phase)
and after 3-6 months (convalescence) in 150 patients with
first-ever ischemic stroke and 150 community controls.
During the acute phase, TF antigen and TFPIf were not
significantly altered but TFPIac was increased (mean 1.27
versus 1.13 U/ml, P U 0.04) and FVIIa was decreased in
cases compared with controls (mean 43.3 versus
57.9 mU/ml, P U 0.0004). After adjusting for baseline
differences between cases and controls, increasing
quartiles of TFPIf were independently associated with
reduced odds of stroke, and reducing quartiles of FVIIa and
increasing quartiles of TFPIac with increased odds of stroke.
During the convalescent phase, FVIIa and TFPIac returned
to normal but TF antigen and TFPIf were significantly
decreased compared with controls [median TF antigen, 110
(follow-up) versus 155 pg/ml (controls), P U 0.0008;
median TFPIf, 15.5 (follow-up) versus 23.3 ng/ml (controls),
P U 0.002]. Alterations of blood concentrations of TF
pathway markers are common in patients with acute
ischemic stroke. The mechanisms are unclear but may
relate to enhanced formation of TF-FVIIa complexes and
upregulation and release of TFPI during the acute phase,
and ongoing consumption of TF antigen and TFPIf during
the chronic phase as the atherosclerotic plaque heals." name="eprints.abstract" />
<meta content="2006-10" name="eprints.date" />
<meta content="published" name="eprints.date_type" />
<meta content="Blood Coagulation and Fibrinolysis" name="eprints.publication" />
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<meta content="0957-5235" name="eprints.issn" />
<meta content="http://dx.doi.org/10.1097/01.mbc.0000245294.41774.06" name="eprints.official_url" />
<meta content="1 McVey JH. Tissue Factor Pathway. Baillieres Best Pract Res Clin Haemat
1999; 12:361-372.
2 Butenas S, Van't Veer C, Mann KG. Evaluation of the initiation phase of
blood coagulation using ultrasensitive assays for serine proteases. J Biol
Chem 1997; 21:527-521.
3 Wun TC, Kretzmer KK, Girard TJ, Miletich JP, Broze GJ. Cloning and
characterisation of a cDNA coding for the lipoprotein-associated
coagulation inhibitor shows that it consists of three tandem kunitz-type
inhibitory domains. J Biol Chem 1988; 263:6001-6004.
4 Girard TJ, Warren LA, Novotny WF, Likert KM, Brown SG, Miletich JP, et al.
Functional significance of the kunitz type inhibitor domains of lipoprotein
associated coagulation inhibitor. Nature 1989; 338:518-520.
5 Kato H. Regulation of functions of vascular wall cells by tissue factor
pathway inhibitor. Arterioscler Thromb Vasc Biol 2002; 22:539-548.
6 Lindahl AK, Sandset PM, Abildgaard U. The present status of tissue factor
pathway inhibitor. Blood Coagul Fibrinolysis 1992; 3:439-449.
7 Hubbard AR, Jennings CA. Inhibition of the tissue factor-factor VIIa
complex: involvement of factor Xa and lipoproteins. Thromb Res 1987; 46:
527-537.
8 Novotny WF, Girard TF, Miletich JP, Broze GJ. Purification and
characterisation of the lipoprotein-associated coagulation inhibitor from
human plasma. J Biol Chem 1989; 264:18832-18837.
9 Novotny WF, Girard TF, Miletich JP, Broze GJ. Platelets secrete a
coagulation inhibitor functionally and antigenically similar to the lipoprotein
associated coagulation inhibitor. Blood 1988; 72:2020-2025.
10 Golino P, Ravera A, Ragni M, Cirillo P, Piro O, Chiariello M. Involvement of
tissue factor pathway inhibitor in the coronary circulation of patients with
acute coronary syndromes. Circulation 2003; 108:2864-2869.
11 Abumiya T, Yamaguchi T, Terasaki T, Kokawa T, Kario K, Kato H. Decreased
plasma tissue factor pathway inhibitor activity in ischemic stroke patients.
Thromb Haemost 1995; 74:1050-1054.
12 He M, Wen Z, He X, Xiong S, Liu F, Xu J, et al. Observation on tissue factor
pathway and some other coagulation parameters during the onset of acute
cerebrocardiac thrombotic diseases. Thromb Res 2002; 107:223-
228.
TF pathway and stroke Adams et al. 531
Copyright Lippincott Williams &amp; Wilkins. Unauthorized reproduction of this article is prohibited.
13 Eikelboom JW, Hankey GJ, Anand SS, Lofthouse E, Staples N, Baker RI.
Association between high homocysteine and ischemic stroke due to large
and small artery disease but not other etiological subtypes of ischemic
stroke. Stroke 2000; 31:1069-1075.
14 Hatano S. Experience from a multicentre stroke register: a preliminary
report. Bull World Health Org 1976; 54:541-553.
15 Warlow CP, Dennis MS, Van Gijn J, Hankey GJ, Sandercock PAG,
Bamford JM. Stroke: a practical guide to management, 2nd ed. Oxford:
Blackwell Scientific Productions; 2000.
16 Sandset PM, Larsen ML, Abildaard U, Odegaard OR. Chromogenic
substrate assay of extrinsic pathway inhibitor (EPI): levels in the normal
population and relation to cholesterol. Blood Coagul Fibrinolysis 1991;
2:425-433.
17 Eilertsen KE, Osterud B. Tissue factor: (patho)physiology and cellular
biology. Blood Coagul Fibrinolysis 2004; 15:521-538.
18 Lindmark E, Siegbahn A. Tissue factor regulation and cytokine expression
in monocyte-endothelial cell co-cultures: effects of a statin, an ACEinhibitor
and a low-molecular-weight heparin. Thromb Res 2002; 108:
77-84.
19 Kopp CW, Steiner S, Priglinger U, Christ G, Probst P, Maurer G, et al.
Parameters of the tissue factor pathway with coumadin/dipyridamole
versus ticlopidine as adjunct antithrombotic-drug regimen in coronary
artery stenting. Blood Coagul Fibrinolysis 2003; 14:379-386.
20 Sebestjen M, Keber I, Zegura B, Simcic S, Bozic M, Fressart MM, et al.
Statin and fibrate treatment of combined hyperlipidemia: the effects on
some novel risk factors. Thromb Haemost 2004; 92:1129-1135.
21 Bartok A, Steiner S, Seidinger D, Jetzl A, Huber K, Minar E, et al.
Atorvastatin reduces thrombin generation after percutaneous coronary
intervention independent of soluble tissue factor. Thromb Res 2005;
115:469-474.
22 Meade TW, Mellows S, Brozovic M, Miller GJ, Chakrabarti RR, North WR,
et al. Haemostatic function and ischaemic heart disease: principal results of
the Northwick Park Heart Study. Lancet 1986; 2:533-537.
23 Kario K, Duell PB, Matsuo T, Sakata T, Kato H, Shimada K, et al. High
plasma homocysteine levels in elderly Japanese patients are associated
with increased cardiovascular disease risk independently from markers of
coagulation activation and endothelial cell damage. Atherosclerosis 2001;
157:441-449.
24 Kang WY, Wang HL, Xiong LF, Wang XF, Chu HY, Qu B, et al.
Polymorphisms of the coagulation factor VII gene and its plasma levels in
relation to acute cerebral infarction differences in allelic frequencies
between Chinese Han and European populations. Chin Med J (Engl)
2004; 117:71-74.
25 Dahm AE, Andersen TO, Rosendaal F, Sandset PM. A novel anticoagulant
activity assay of tissue factor pathway inhibitor I (TFPI). J Thromb Haemost
2005; 3:651-658.
26 Hansen JB, Huseby KR, Huseby NE, Ezban M, Nordoy A. Tissue factor
pathway inhibitor in complex with low density lipoprotein isolated from
human plasma does not possess anticoagulant function in tissue factorinduced
coagulation in vitro. Thromb Res 1997; 85:413-425.
27 Hirsh J, O'Donnell M, Weitz JI. New anticoagulants. Blood 2005; 105:
453-463." name="eprints.referencetext" />
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<meta content="Eikelboom, J.W." name="DC.creator" />
<meta content="321008 Haematology" name="DC.subject" />
<meta content="To explore the role of the the tissue factor (TF) pathway in
ischemic stroke. We measured blood concentrations of
markers of the TF pathway [TF antigen, free tissue factor
pathway inhibitor antigen (TFPIf) and activity (TFPIac), and
activated factor VII (FVIIa)] within 7 days (acute phase)
and after 3-6 months (convalescence) in 150 patients with
first-ever ischemic stroke and 150 community controls.
During the acute phase, TF antigen and TFPIf were not
significantly altered but TFPIac was increased (mean 1.27
versus 1.13 U/ml, P U 0.04) and FVIIa was decreased in
cases compared with controls (mean 43.3 versus
57.9 mU/ml, P U 0.0004). After adjusting for baseline
differences between cases and controls, increasing
quartiles of TFPIf were independently associated with
reduced odds of stroke, and reducing quartiles of FVIIa and
increasing quartiles of TFPIac with increased odds of stroke.
During the convalescent phase, FVIIa and TFPIac returned
to normal but TF antigen and TFPIf were significantly
decreased compared with controls [median TF antigen, 110
(follow-up) versus 155 pg/ml (controls), P U 0.0008;
median TFPIf, 15.5 (follow-up) versus 23.3 ng/ml (controls),
P U 0.002]. Alterations of blood concentrations of TF
pathway markers are common in patients with acute
ischemic stroke. The mechanisms are unclear but may
relate to enhanced formation of TF-FVIIa complexes and
upregulation and release of TFPI during the acute phase,
and ongoing consumption of TF antigen and TFPIf during
the chronic phase as the atherosclerotic plaque heals." name="DC.description" />
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    <h1 class="ep_tm_pagetitle">The tissue factor pathway in ischemic stroke</h1>
    <p style="margin-bottom: 1em" class="not_ep_block"><span class="person_name">Adams, M.J.</span> and <span class="person_name">Thom, J.</span> and <span class="person_name">Hankey, G.J.</span> and <span class="person_name">Baker, Ross I.</span> and <span class="person_name">Gilmore, G.</span> and <span class="person_name">Staton, J.M.</span> and <span class="person_name">Eikelboom, J.W.</span> (2006) <xhtml:em>The tissue factor pathway in ischemic stroke.</xhtml:em> Blood Coagulation and Fibrinolysis, 17 (7). pp. 527-532. ISSN 0957-5235</p><p style="margin-bottom: 1em" class="not_ep_block"></p><table style="margin-bottom: 1em" class="not_ep_block"><tr><td valign="top" style="text-align:center"><a href="http://eprints.utas.edu.au/1776/1/Adams_et_al_2006.pdf"><img alt="[img]" src="http://eprints.utas.edu.au/style/images/fileicons/application_pdf.png" class="ep_doc_icon" border="0" /></a></td><td valign="top"><a href="http://eprints.utas.edu.au/1776/1/Adams_et_al_2006.pdf"><span class="ep_document_citation">PDF</span></a> - Full text restricted - Requires a PDF viewer<br />166Kb</td></tr></table><p style="margin-bottom: 1em" class="not_ep_block">Official URL: <a href="http://dx.doi.org/10.1097/01.mbc.0000245294.41774.06">http://dx.doi.org/10.1097/01.mbc.0000245294.41774.06</a></p><div class="not_ep_block"><h2>Abstract</h2><p style="padding-bottom: 16px; text-align: left; margin: 1em auto 0em auto">To explore the role of the the tissue factor (TF) pathway in&#13;
ischemic stroke. We measured blood concentrations of&#13;
markers of the TF pathway [TF antigen, free tissue factor&#13;
pathway inhibitor antigen (TFPIf) and activity (TFPIac), and&#13;
activated factor VII (FVIIa)] within 7 days (acute phase)&#13;
and after 3-6 months (convalescence) in 150 patients with&#13;
first-ever ischemic stroke and 150 community controls.&#13;
During the acute phase, TF antigen and TFPIf were not&#13;
significantly altered but TFPIac was increased (mean 1.27&#13;
versus 1.13 U/ml, P U 0.04) and FVIIa was decreased in&#13;
cases compared with controls (mean 43.3 versus&#13;
57.9 mU/ml, P U 0.0004). After adjusting for baseline&#13;
differences between cases and controls, increasing&#13;
quartiles of TFPIf were independently associated with&#13;
reduced odds of stroke, and reducing quartiles of FVIIa and&#13;
increasing quartiles of TFPIac with increased odds of stroke.&#13;
During the convalescent phase, FVIIa and TFPIac returned&#13;
to normal but TF antigen and TFPIf were significantly&#13;
decreased compared with controls [median TF antigen, 110&#13;
(follow-up) versus 155 pg/ml (controls), P U 0.0008;&#13;
median TFPIf, 15.5 (follow-up) versus 23.3 ng/ml (controls),&#13;
P U 0.002]. Alterations of blood concentrations of TF&#13;
pathway markers are common in patients with acute&#13;
ischemic stroke. The mechanisms are unclear but may&#13;
relate to enhanced formation of TF-FVIIa complexes and&#13;
upregulation and release of TFPI during the acute phase,&#13;
and ongoing consumption of TF antigen and TFPIf during&#13;
the chronic phase as the atherosclerotic plaque heals.</p></div><table style="margin-bottom: 1em" cellpadding="3" class="not_ep_block" border="0"><tr><th valign="top" class="ep_row">Item Type:</th><td valign="top" class="ep_row">Article</td></tr><tr><th valign="top" class="ep_row">Additional Information:</th><td valign="top" class="ep_row">The definitive version is available online at www.bloodcoagulation.com/</td></tr><tr><th valign="top" class="ep_row">Keywords:</th><td valign="top" class="ep_row">tissue factor, stroke, factor VII, tissue factor pathway inhibitor</td></tr><tr><th valign="top" class="ep_row">Subjects:</th><td valign="top" class="ep_row"><a href="http://eprints.utas.edu.au/view/subjects/321008.html">320000 Medical and Health Sciences &gt; 321000 Clinical Sciences &gt; 321008 Haematology</a></td></tr><tr><th valign="top" class="ep_row">ID Code:</th><td valign="top" class="ep_row">1776</td></tr><tr><th valign="top" class="ep_row">Deposited By:</th><td valign="top" class="ep_row"><span class="ep_name_citation"><span class="person_name">Dr Murray J Adams</span></span></td></tr><tr><th valign="top" class="ep_row">Deposited On:</th><td valign="top" class="ep_row">27 Sep 2007</td></tr><tr><th valign="top" class="ep_row">Last Modified:</th><td valign="top" class="ep_row">09 Jan 2008 02:30</td></tr><tr><th valign="top" class="ep_row">ePrint Statistics:</th><td valign="top" class="ep_row"><a target="ePrintStats" href="/es/index.php?action=show_detail_eprint;id=1776;">View statistics for this ePrint</a></td></tr></table><p align="right">Repository Staff Only: <a href="http://eprints.utas.edu.au/cgi/users/home?screen=EPrint::View&amp;eprintid=1776">item control page</a></p>
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