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<title>UTas ePrints - Cellular and molecular biology of ensheathing cells</title>
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<meta content="Chuah, Meng Inn" name="eprints.creators_name" />
<meta content="West, A.K." name="eprints.creators_name" />
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<meta content="Cellular and molecular biology of ensheathing cells" name="eprints.title" />
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<meta content="primary olfactory pathway; axon growth; growth factors; receptors; neural repair" name="eprints.keywords" />
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<meta content="ABSTRACT Ensheathing cells are the glial cells that envelop olfactory axons as they course
from the olfactory epithelium to the bulb. They are derived from the olfactory placode and differ
from the typical glia in terms of sharing the phenotypes of both astrocytes and Schwann cells. The
aims of this study are to review (1) cellular characterisation of ensheathing cells in vivo and in vitro,
(2) molecular insight into their growth promoting properties, and (3) their role in olfactory development
and potential function as a therapeutic agent for nerve repair. Much of the characterisation
of ensheathing cell property has developed from immunohistochemical studies that have been
supplemented with new molecular methodologies in recent years. Many pieces of evidence clearly
indicate that ensheathing cells actively produce growth-promoting molecules, which act in a
paracrine and, in some cases, autocrine manner. However, a review of the available literature also
suggests that there is a great deal that remains to be elucidated regarding the cell biology of
ensheathing cells, for example, their rate of formation and turnover. In addition, the apparent
antigenic heterogeneity as revealed by numerous in vitro studies warrants further analysis,
particularly in view of the fact that in recent years these cells have been touted as a possible agent
for central nerve repair. New molecular methodologies such as the microarray techniques will prove
to be crucial for defining the unique characteristics of ensheathing cells. Microsc. Res. Tech. 58:" name="eprints.abstract" />
<meta content="2002" name="eprints.date" />
<meta content="published" name="eprints.date_type" />
<meta content="Microscopy Research and Technique" name="eprints.publication" />
<meta content="58" name="eprints.volume" />
<meta content="216-227" name="eprints.pagerange" />
<meta content="10.1002/jemt.10151" name="eprints.id_number" />
<meta content="TRUE" name="eprints.refereed" />
<meta content="1059-910X" name="eprints.issn" />
<meta content="http://dx.doi.org/10.1002/jemt.10151" name="eprints.official_url" />
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Fig. 3. Lesioned spinal cord implanted with polymer capsule (arrow)
containing ensheathing cells. The capsule is placed beneath the
dura and immediately above the dorsal columns. Inset: A capsule
that has been sectioned to reveal some of the ensheathing cells
present within it. Bar 4 mm; bar in inset 50 m.
CELL BIOLOGY OF ENSHEATHING CELLS 225
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<meta content="ABSTRACT Ensheathing cells are the glial cells that envelop olfactory axons as they course
from the olfactory epithelium to the bulb. They are derived from the olfactory placode and differ
from the typical glia in terms of sharing the phenotypes of both astrocytes and Schwann cells. The
aims of this study are to review (1) cellular characterisation of ensheathing cells in vivo and in vitro,
(2) molecular insight into their growth promoting properties, and (3) their role in olfactory development
and potential function as a therapeutic agent for nerve repair. Much of the characterisation
of ensheathing cell property has developed from immunohistochemical studies that have been
supplemented with new molecular methodologies in recent years. Many pieces of evidence clearly
indicate that ensheathing cells actively produce growth-promoting molecules, which act in a
paracrine and, in some cases, autocrine manner. However, a review of the available literature also
suggests that there is a great deal that remains to be elucidated regarding the cell biology of
ensheathing cells, for example, their rate of formation and turnover. In addition, the apparent
antigenic heterogeneity as revealed by numerous in vitro studies warrants further analysis,
particularly in view of the fact that in recent years these cells have been touted as a possible agent
for central nerve repair. New molecular methodologies such as the microarray techniques will prove
to be crucial for defining the unique characteristics of ensheathing cells. Microsc. Res. Tech. 58:" name="DC.description" />
<meta content="2002" name="DC.date" />
<meta content="Article" name="DC.type" />
<meta content="PeerReviewed" name="DC.type" />
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<h1 class="ep_tm_pagetitle">Cellular and molecular biology of ensheathing cells</h1>
<p style="margin-bottom: 1em" class="not_ep_block"><span class="person_name">Chuah, Meng Inn</span> and <span class="person_name">West, A.K.</span> (2002) <xhtml:em>Cellular and molecular biology of ensheathing cells.</xhtml:em> Microscopy Research and Technique, 58 . pp. 216-227. ISSN 1059-910X</p><p style="margin-bottom: 1em" class="not_ep_block"></p><table style="margin-bottom: 1em" class="not_ep_block"><tr><td valign="top" style="text-align:center"><a href="http://eprints.utas.edu.au/2220/1/Chuah_and_West2002.pdf"><img alt="[img]" src="http://eprints.utas.edu.au/style/images/fileicons/application_pdf.png" class="ep_doc_icon" border="0" /></a></td><td valign="top"><a href="http://eprints.utas.edu.au/2220/1/Chuah_and_West2002.pdf"><span class="ep_document_citation">PDF</span></a> - Full text restricted - Requires a PDF viewer<br />1676Kb</td><td><form method="get" accept-charset="utf-8" action="http://eprints.utas.edu.au/cgi/request_doc"><input accept-charset="utf-8" value="2789" name="docid" type="hidden" /><div class=""><input value="Request a copy" name="_action_null" class="ep_form_action_button" onclick="return EPJS_button_pushed( '_action_null' )" type="submit" /> </div></form></td></tr></table><p style="margin-bottom: 1em" class="not_ep_block">Official URL: <a href="http://dx.doi.org/10.1002/jemt.10151">http://dx.doi.org/10.1002/jemt.10151</a></p><div class="not_ep_block"><h2>Abstract</h2><p style="padding-bottom: 16px; text-align: left; margin: 1em auto 0em auto">ABSTRACT Ensheathing cells are the glial cells that envelop olfactory axons as they course
from the olfactory epithelium to the bulb. They are derived from the olfactory placode and differ
from the typical glia in terms of sharing the phenotypes of both astrocytes and Schwann cells. The
aims of this study are to review (1) cellular characterisation of ensheathing cells in vivo and in vitro,
(2) molecular insight into their growth promoting properties, and (3) their role in olfactory development
and potential function as a therapeutic agent for nerve repair. Much of the characterisation
of ensheathing cell property has developed from immunohistochemical studies that have been
supplemented with new molecular methodologies in recent years. Many pieces of evidence clearly
indicate that ensheathing cells actively produce growth-promoting molecules, which act in a
paracrine and, in some cases, autocrine manner. However, a review of the available literature also
suggests that there is a great deal that remains to be elucidated regarding the cell biology of
ensheathing cells, for example, their rate of formation and turnover. In addition, the apparent
antigenic heterogeneity as revealed by numerous in vitro studies warrants further analysis,
particularly in view of the fact that in recent years these cells have been touted as a possible agent
for central nerve repair. New molecular methodologies such as the microarray techniques will prove
to be crucial for defining the unique characteristics of ensheathing cells. Microsc. Res. Tech. 58:</p></div><table style="margin-bottom: 1em" cellpadding="3" class="not_ep_block" border="0"><tr><th valign="top" class="ep_row">Item Type:</th><td valign="top" class="ep_row">Article</td></tr><tr><th valign="top" class="ep_row">Additional Information:</th><td valign="top" class="ep_row">see individual journal copyright transfer agreements</td></tr><tr><th valign="top" class="ep_row">Keywords:</th><td valign="top" class="ep_row">primary olfactory pathway; axon growth; growth factors; receptors; neural repair</td></tr><tr><th valign="top" class="ep_row">Subjects:</th><td valign="top" class="ep_row"><a href="http://eprints.utas.edu.au/view/subjects/320000.html">320000 Medical and Health Sciences</a><br /><a href="http://eprints.utas.edu.au/view/subjects/270000.html">270000 Biological Sciences</a></td></tr><tr><th valign="top" class="ep_row">ID Code:</th><td valign="top" class="ep_row">2220</td></tr><tr><th valign="top" class="ep_row">Deposited By:</th><td valign="top" class="ep_row"><span class="ep_name_citation"><span class="person_name">A/Prof MI Chuah</span></span></td></tr><tr><th valign="top" class="ep_row">Deposited On:</th><td valign="top" class="ep_row">17 Oct 2007 16:16</td></tr><tr><th valign="top" class="ep_row">Last Modified:</th><td valign="top" class="ep_row">09 Jan 2008 02:30</td></tr><tr><th valign="top" class="ep_row">ePrint Statistics:</th><td valign="top" class="ep_row"><a target="ePrintStats" href="/es/index.php?action=show_detail_eprint;id=2220;">View statistics for this ePrint</a></td></tr></table><p align="right">Repository Staff Only: <a href="http://eprints.utas.edu.au/cgi/users/home?screen=EPrint::View&eprintid=2220">item control page</a></p>
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