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<title>UTas ePrints - Tissue factor pathway inhibitor: Regulator of the tissue factor pathway of coagulation and a future antithrombotic agent?</title>
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<meta content="Adams, M.J." name="eprints.creators_name" />
<meta content="Oostryck, R." name="eprints.creators_name" />
<meta content="Murray.Adams@utas.edu.au" name="eprints.creators_id" />
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<meta content="2007-11-02 00:22:21" name="eprints.datestamp" />
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<meta content="Tissue factor pathway inhibitor: Regulator of the tissue factor pathway of coagulation and a future antithrombotic agent?" name="eprints.title" />
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<meta content="Antithrombotic agent; Coagulation; Thrombosis; Tissue factor; Tissue factor pathway inhibitor
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<meta content="Tissue factor pathway inhibitor (TFPI) is a recently 'rediscovered' inhibitor of tissue factor mediated coagulation that has a central role in the modern hypothesis of coagulation. The regulatory role of this inhibitor has redefined the classical extrinsic and intrinsic pathways of coagulation and helps to explain why haemophiliacs bleed. Comprehensive investigations have been performed during the last 15 years to elucidate the structure, distribution, function and physiological characteristics of TFPI. More recent work has focused on the therapeutic potential of TFPI as an antithrombotic agent. Augmentation of TFPI levels may provide treatment for thrombotic disorders such as disseminated intravascular coagulation and deep vein thrombosis. Full length and truncated forms of TFPI molecules are also being considered as antithrombotic agents. These have been used in a number of animal models with initial results demonstrating the alleviation of thrombotic tendencies. Trials are currently ongoing." name="eprints.abstract" />
<meta content="2000" name="eprints.date" />
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<meta content="1038-1643" name="eprints.issn" />
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<meta content="1.Davie, E.W., Ratnoff, O.D.
Waterfall sequence for intrinsic blood clotting
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An enzyme cascade in the blood clotting mechanism, and its function as a biochemical amplifier
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Inhibition of tissue factor/factor VIIa activity in plasma requires factor X and an additional plasma component
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4Loeb, L., Fleisher, M.S., Tuttle, L.
The interaction between blood serum and tissue extract in the coagulation of blood. i the combined action of serum and tissue extract on fluoride, hirudin and peptone plasma, and the effect of heating on serum
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Intermediate reactions in the coagulation of blood with tissue thromboplastin
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An alternative extrinsic pathway of human blood coagulation
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Structure of the human lipoprotein-associated coagulation inhibitor gene: Intro/exon gene organization and localization of the gene to chromosome 2
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8. Wun, T.-C., Kretzmer, K.K., Girard, T.J., Miletich, J.P., Broze Jr., G.J.
Cloning and characterization of a cDNA coding for the lipoprotein-associated coagulation inhibitor shows that it consists of three tandem Kunitz-type inhibitory domains
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Regulation of coagulation by a multivalent Kunitz-type inhibitor
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The present status of tissue factor pathway inhibitor
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Why do hemophiliacs bleed?
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Plasma levels of tissue factor pathway inhibitor in thrombophilic patients
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Low levels of tissue factor pathway inhibitor (TFPI) in two out of three members of a family with thrombophilia.
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Tissue factor pathway inhibitor with high anticoagulant activity is increased in post-heparin plasma and in plasma from cancer patients.
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Evidence that the C-terminus of tissue factor pathwway inhibitor (TFPI) is essential for its interaction with lipoproteins
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Blocking of tissue factor pathway inhibitor (TFPI) shortens the bleeding time in rabbits with antibody induced hemophilia A
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58. Holst, J., Lindblad, B., Bergqvist, D., Nordfang, O., Ostergaard, P.B., Petersen, J.G.L., Nielsen, G., (...), Hedner, U.
Antithrombotic effect of recombinant truncated tissue factor pathway inhibitor (TFPI) in experimental venous thrombosis: A comparison with low molecular weight heparin
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Inhibitory properties of full-length and truncated recombinant tissue factor pathway inhibitor (TFPI). Evidence that the third Kunitz-type domain of TFPI is not essential for the inhibition of factor VIIa-tissue factor complexes on cell surfaces
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Tissue factor pathway inhibitor (TFPI) and its response to heparin in patients with spontaneous deep vein thrombosis
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Inhibition of a factor VIIa-tissue factor coagulation activity by a hybrid protein
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Bacterial expression, purification, and partial characterization of amino acids 94-155 of human tissue factor pathway inhibitor (TFPI) as an inhibitor of blood coagulation factor XA
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64. Lindhout, T., Franssen, J., Willems, G.
Kinetics of the inhibition of tissue factor-factor VIIa by tissue factor pathway inhibitor
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65. Broze Jr., G.J.
Tissue factor pathway inhibitor
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66. Enjoyji, K., Miyata, T., Kamikubo, Y., Kato, J.
Effect of heparin on the inhibition of FXa by tissue factor pathway inhibitor: A segment, Gly212- Phe 243, of the third kunitz domain is a heparin binding site
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Tissue factor pathway inhibitor: Potential therapeutic applications
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Pharmacokinetics and delayed experimental anti-thrombotic effect of two domain non-glycosylated tissue factor pathway inhibitor
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70. Day, K.C., Hoffman, L.C., Palmier, M.O., Kretzmer, K.K., Huang, M.D., Pyla, E.Y., Spokas, E., (...), Wun, T.-C.
Recombinant lipoprotein-associated coagulation inhibitor inhibits tissue thromboplastin-induced intravascular coagulation in the rabbit
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71. Bregengard, C., Nordfang, O., Wildgoose, P., Svendsen, O., Hedner, U., Diness, V.
The effect of two-domain tissue factor pathway inhibitor on endotoxin-induced disseminated intravascular coagulation in rabbits
(1993) Blood Coagulation and Fibrinolysis, 4 (5), pp. 699-706. Cited 49 times.
72. Camerota, A.J., Creasey, A.A., Patla, V., Larkin, V.A., Fink, M.P.
Delayed treatment with recombinant human tissue factor pathway inhibitor improves survival in rabbits with gram-negative peritonitis
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73. Girard, T.J.
Tissue factor pathway inhibitor
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Sasahara A, Loscalzo J, eds. New York: Marcel Dekker
Oostryck, R.; School of Biomedical Sciences, Curtin University of Technology, GPO Box U 1987, Perth, WA 6845, Australia; email:r.oostryck@info.curtin.edu.au
© Copyright 2006 Elsevier B.V., All rights reserved
1.Davie, E.W., Ratnoff, O.D.
Waterfall sequence for intrinsic blood clotting
(1964) Science, 145, pp. 1310-1312. Cited 171 times.
2. MacFarlane, R.G.
An enzyme cascade in the blood clotting mechanism, and its function as a biochemical amplifier
(1964) Nature, 202, pp. 498-499. Cited 162 times.
3. Sanders, N.L., Bajaj, S.P., Zivelin, A., Rapaport, S.I.
Inhibition of tissue factor/factor VIIa activity in plasma requires factor X and an additional plasma component
(1985) Blood, 66 (1), pp. 204-212. Cited 37 times.
4Loeb, L., Fleisher, M.S., Tuttle, L.
The interaction between blood serum and tissue extract in the coagulation of blood. i the combined action of serum and tissue extract on fluoride, hirudin and peptone plasma, and the effect of heating on serum
(1922) J Biol Chem, 51, pp. 461-484. Cited 2 times.
5. Hjort, P.F.
Intermediate reactions in the coagulation of blood with tissue thromboplastin
(1957) Scand J Clin Lab Invest, 9, pp. 1-182. Cited 34 times.
6. Marlar, R.A., Kleiss, A.J., Griffin, J.H.
An alternative extrinsic pathway of human blood coagulation
(1982) Blood, 60 (6), pp. 1353-1358. Cited 24 times.
7. Girard, T.J., Eddy, R., Wesselschmidt, R.L., MacPhail, L.A., Likert, K.M., Byers, M.G., Shows, T.B., (...), Broze Jr., G.J.
Structure of the human lipoprotein-associated coagulation inhibitor gene: Intro/exon gene organization and localization of the gene to chromosome 2
(1991) Journal of Biological Chemistry, 266 (8), pp. 5036-5041. Cited 29 times.
8. Wun, T.-C., Kretzmer, K.K., Girard, T.J., Miletich, J.P., Broze Jr., G.J.
Cloning and characterization of a cDNA coding for the lipoprotein-associated coagulation inhibitor shows that it consists of three tandem Kunitz-type inhibitory domains
(1988) Journal of Biological Chemistry, 263 (13), pp. 6001-6004. Cited 146 times.
9. Broze Jr., G.J., Girard, T.J., Novotny, W.F.
Regulation of coagulation by a multivalent Kunitz-type inhibitor
(1990) Biochemistry, 29 (33), pp. 7539-7546. Cited 180 times.
10. Lindahl, A.K., Sandset, P.M., Abildgaard, U.
The present status of tissue factor pathway inhibitor
(1992) Blood Coagulation and Fibrinolysis, 3 (4), pp. 439-449. Cited 84 times.
11. Broze Jr., G.J.
Why do hemophiliacs bleed?
(1992) Hospital Practice, 27 (3), pp. 71-74+79. Cited 8 times.
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Tissue factor pathway inhibitor with high anticoagulant activity is increased in post-heparin plasma and in plasma from cancer patients.
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Is tissue factor pathway inhibitor involved in the antithrombotic effect of heparins? Biochemical considerations
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Effect of protamine on heparin releasable TFPI antigen levels in normal volunteers
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Comparative effects of enoxaparin and unfractionated heparin in healthy volunteers on prothrombin consumption in whole blood during coagulation, and release of tissue factor pathway inhibitor
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51. Abildgaard, U.
Heparin/low molecular weight heparin and tissue factor pathway inhibitor
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52. Hansen, J.-B., Sandset, P.M., Huseby, K.R., Huseby, N.-E., Bendz, B., Østergaard, P., Nordøy, A.
Differential effect of unfractionated heparin and low molecular weight heparin on intravascular tissue factor pathway inhibitor: Evidence for a difference in antithrombotic action
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Inhibitory effects of TFPI on thrombin and factor Xa generation in vitromodulatory action of glycosaminoglycans
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54. Wun, T.-C.
Lipoprotein-associated coagulation inhibitor (LACI) is a cofactor for heparin: Synergistic anticoagulant action between LACI and sulfated polysaccharides
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55. Wesselschmidt, R., Likert, K., Girard, T., Wun, T.-C., Broze Jr., G.J.
Tissue factor pathway inhibitor: The carboxy-terminus is required for optimal inhibition of factor Xa
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56. Kijowski, R., Hoppensteadt, D., Walenga, J., Borris, L., Lassen, M.R., Fareed, J.
Role of tissue factor pathway inhibitor in post surgical deep venous thrombosis (DVT) prophylaxis in patients treated with low molecular weight heparin
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57. Erhardtsen, E., Madsen, M.T., Ezban, M., Hedner, U., Diness, V., Glazer, S., Nordfang, O.
Blocking of tissue factor pathway inhibitor (TFPI) shortens the bleeding time in rabbits with antibody induced hemophilia A
(1993) Thromb Haemost, 69, p. 556. Cited 5 times.
58. Holst, J., Lindblad, B., Bergqvist, D., Nordfang, O., Ostergaard, P.B., Petersen, J.G.L., Nielsen, G., (...), Hedner, U.
Antithrombotic effect of recombinant truncated tissue factor pathway inhibitor (TFPI) in experimental venous thrombosis: A comparison with low molecular weight heparin
(1994) Thrombosis and Haemostasis, 71 (2), pp. 214-219. Cited 36 times.
59. Hamamoto, T., Yamamoto, M., Nordfang, O., Petersen, J.G.L., Foster, D.C., Kisiel, W.
Inhibitory properties of full-length and truncated recombinant tissue factor pathway inhibitor (TFPI). Evidence that the third Kunitz-type domain of TFPI is not essential for the inhibition of factor VIIa-tissue factor complexes on cell surfaces
(1993) Journal of Biological Chemistry, 268 (12), pp. 8704-8710. Cited 41 times.
60. Holst, J., Lindblad, B., Wedeberg, E., Bergqvist, D., Nordfang, O., Ostergaard, P.B., Hedner, U.
Tissue factor pathway inhibitor (TFPI) and its response to heparin in patients with spontaneous deep vein thrombosis
(1993) Thrombosis Research, 72 (5), pp. 467-470. Cited 11 times.
doi: 10.1016/0049-3848(93)90248-M
61. Girard, T.J., MacPhail, L.A., Likert, K.M., Novotny, W.F., Miletich, J.P., Broze Jr., G.J.
Inhibition of a factor VIIa-tissue factor coagulation activity by a hybrid protein
(1990) Science, 248 (4961), pp. 1421-1424. Cited 38 times.
62. Day, K.C., Welsch, D.J.
Bacterial expression, purification, and partial characterization of amino acids 94-155 of human tissue factor pathway inhibitor (TFPI) as an inhibitor of blood coagulation factor XA
(1992) Thrombosis Research, 68 (4-5), pp. 369-381. Cited 6 times.
doi: 10.1016/0049-3848(92)90095-R
63. Eisenberg, P.R., Siegel, J.E., Abendschein, D.R., Miletich, J.P.
Importance of factor Xa in determining the procoagulant activity of whole- blood clots
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64. Lindhout, T., Franssen, J., Willems, G.
Kinetics of the inhibition of tissue factor-factor VIIa by tissue factor pathway inhibitor
(1995) Thrombosis and Haemostasis, 74 (3), pp. 910-915. Cited 40 times.
65. Broze Jr., G.J.
Tissue factor pathway inhibitor
(1995) Thrombosis and Haemostasis, 74 (1), pp. 90-93. Cited 206 times.
66. Enjoyji, K., Miyata, T., Kamikubo, Y., Kato, J.
Effect of heparin on the inhibition of FXa by tissue factor pathway inhibitor: A segment, Gly212- Phe 243, of the third kunitz domain is a heparin binding site
(1995) Biochemistry, 34, pp. 5727-5735.
67. Bajaj, M.S., Bajaj, S.P.
Tissue factor pathway inhibitor: Potential therapeutic applications
(1997) Thrombosis and Haemostasis, 78 (1), pp. 471-477. Cited 94 times.
68. Kamikubo, Y.-I., Hamuro, T., Matsuda, J.-I., Kamei, S., Jyu-Ri, K., Miyamoto, S., Funatsu, A., (...), Kato, H.
The clearance of proteoglycan-associated human recombinant tissue factor pathway inhibitor (H-RTFPI) in rabbits: A complex formation of H- RTFPI with factor Xa promotes a clearance rate of H-RTFPI
(1996) Thrombosis Research, 83 (2), pp. 161-173. Cited 9 times.
doi: 10.1016/0049-3848(96)00117-X
69. Holst, J., Lindblad, B., Westerlund, G., Bregengaard, C., Ezban, M., ØStergaard, P.B., Nordfang, O., (...), Hedner, U.
Pharmacokinetics and delayed experimental anti-thrombotic effect of two domain non-glycosylated tissue factor pathway inhibitor
(1996) Thrombosis Research, 81 (4), pp. 461-470. Cited 6 times.
doi: 10.1016/0049-3848(96)00018-7
70. Day, K.C., Hoffman, L.C., Palmier, M.O., Kretzmer, K.K., Huang, M.D., Pyla, E.Y., Spokas, E., (...), Wun, T.-C.
Recombinant lipoprotein-associated coagulation inhibitor inhibits tissue thromboplastin-induced intravascular coagulation in the rabbit
(1990) Blood, 76 (8), pp. 1538-1545. Cited 40 times.
71. Bregengard, C., Nordfang, O., Wildgoose, P., Svendsen, O., Hedner, U., Diness, V.
The effect of two-domain tissue factor pathway inhibitor on endotoxin-induced disseminated intravascular coagulation in rabbits
(1993) Blood Coagulation and Fibrinolysis, 4 (5), pp. 699-706. Cited 49 times.
72. Camerota, A.J., Creasey, A.A., Patla, V., Larkin, V.A., Fink, M.P.
Delayed treatment with recombinant human tissue factor pathway inhibitor improves survival in rabbits with gram-negative peritonitis
(1998) Journal of Infectious Diseases, 177 (3), pp. 668-676. Cited 63 times.
73. Girard, T.J.
Tissue factor pathway inhibitor
(1997) Novel Therapeutic Agents in Thrombosis and Thrombolysis, pp. 225-260. Cited 8 times.
Sasahara A, Loscalzo J, eds. New York: Marcel Dekker
Oostryck, R.; School of Biomedical Sciences, Curtin University of Technology, GPO Box U 1987, Perth, WA 6845, Australia; email:r.oostryck@info.curtin.edu.au
© Copyright 2006 Elsevier B.V., All rights reserved
57. Erhardtsen, E., Madsen, M.T., Ezban, M., Hedner, U., Diness, V., Glazer, S., Nordfang, O.
Blocking of tissue factor pathway inhibitor (TFPI) shortens the bleeding time in rabbits with antibody induced hemophilia A
(1993) Thromb Haemost, 69, p. 556. Cited 5 times.
58. Holst, J., Lindblad, B., Bergqvist, D., Nordfang, O., Ostergaard, P.B., Petersen, J.G.L., Nielsen, G., (...), Hedner, U.
Antithrombotic effect of recombinant truncated tissue factor pathway inhibitor (TFPI) in experimental venous thrombosis: A comparison with low molecular weight heparin
(1994) Thrombosis and Haemostasis, 71 (2), pp. 214-219. Cited 36 times.
59. Hamamoto, T., Yamamoto, M., Nordfang, O., Petersen, J.G.L., Foster, D.C., Kisiel, W.
Inhibitory properties of full-length and truncated recombinant tissue factor pathway inhibitor (TFPI). Evidence that the third Kunitz-type domain of TFPI is not essential for the inhibition of factor VIIa-tissue factor complexes on cell surfaces
(1993) Journal of Biological Chemistry, 268 (12), pp. 8704-8710. Cited 41 times.
60. Holst, J., Lindblad, B., Wedeberg, E., Bergqvist, D., Nordfang, O., Ostergaard, P.B., Hedner, U.
Tissue factor pathway inhibitor (TFPI) and its response to heparin in patients with spontaneous deep vein thrombosis
(1993) Thrombosis Research, 72 (5), pp. 467-470. Cited 11 times.
doi: 10.1016/0049-3848(93)90248-M
61. Girard, T.J., MacPhail, L.A., Likert, K.M., Novotny, W.F., Miletich, J.P., Broze Jr., G.J.
Inhibition of a factor VIIa-tissue factor coagulation activity by a hybrid protein
(1990) Science, 248 (4961), pp. 1421-1424. Cited 38 times.
62. Day, K.C., Welsch, D.J.
Bacterial expression, purification, and partial characterization of amino acids 94-155 of human tissue factor pathway inhibitor (TFPI) as an inhibitor of blood coagulation factor XA
(1992) Thrombosis Research, 68 (4-5), pp. 369-381. Cited 6 times.
doi: 10.1016/0049-3848(92)90095-R
63. Eisenberg, P.R., Siegel, J.E., Abendschein, D.R., Miletich, J.P.
Importance of factor Xa in determining the procoagulant activity of whole- blood clots
(1993) Journal of Clinical Investigation, 91 (5), pp. 1877-1883. Cited 108 times.
64. Lindhout, T., Franssen, J., Willems, G.
Kinetics of the inhibition of tissue factor-factor VIIa by tissue factor pathway inhibitor
(1995) Thrombosis and Haemostasis, 74 (3), pp. 910-915. Cited 40 times.
65. Broze Jr., G.J.
Tissue factor pathway inhibitor
(1995) Thrombosis and Haemostasis, 74 (1), pp. 90-93. Cited 206 times.
66. Enjoyji, K., Miyata, T., Kamikubo, Y., Kato, J.
Effect of heparin on the inhibition of FXa by tissue factor pathway inhibitor: A segment, Gly212- Phe 243, of the third kunitz domain is a heparin binding site
(1995) Biochemistry, 34, pp. 5727-5735.
67. Bajaj, M.S., Bajaj, S.P.
Tissue factor pathway inhibitor: Potential therapeutic applications
(1997) Thrombosis and Haemostasis, 78 (1), pp. 471-477. Cited 94 times.
68. Kamikubo, Y.-I., Hamuro, T., Matsuda, J.-I., Kamei, S., Jyu-Ri, K., Miyamoto, S., Funatsu, A., (...), Kato, H.
The clearance of proteoglycan-associated human recombinant tissue factor pathway inhibitor (H-RTFPI) in rabbits: A complex formation of H- RTFPI with factor Xa promotes a clearance rate of H-RTFPI
(1996) Thrombosis Research, 83 (2), pp. 161-173. Cited 9 times.
doi: 10.1016/0049-3848(96)00117-X
69. Holst, J., Lindblad, B., Westerlund, G., Bregengaard, C., Ezban, M., ØStergaard, P.B., Nordfang, O., (...), Hedner, U.
Pharmacokinetics and delayed experimental anti-thrombotic effect of two domain non-glycosylated tissue factor pathway inhibitor
(1996) Thrombosis Research, 81 (4), pp. 461-470. Cited 6 times.
doi: 10.1016/0049-3848(96)00018-7
70. Day, K.C., Hoffman, L.C., Palmier, M.O., Kretzmer, K.K., Huang, M.D., Pyla, E.Y., Spokas, E., (...), Wun, T.-C.
Recombinant lipoprotein-associated coagulation inhibitor inhibits tissue thromboplastin-induced intravascular coagulation in the rabbit
(1990) Blood, 76 (8), pp. 1538-1545. Cited 40 times.
71. Bregengard, C., Nordfang, O., Wildgoose, P., Svendsen, O., Hedner, U., Diness, V.
The effect of two-domain tissue factor pathway inhibitor on endotoxin-induced disseminated intravascular coagulation in rabbits
(1993) Blood Coagulation and Fibrinolysis, 4 (5), pp. 699-706. Cited 49 times.
72. Camerota, A.J., Creasey, A.A., Patla, V., Larkin, V.A., Fink, M.P.
Delayed treatment with recombinant human tissue factor pathway inhibitor improves survival in rabbits with gram-negative peritonitis
(1998) Journal of Infectious Diseases, 177 (3), pp. 668-676. Cited 63 times.
73. Girard, T.J.
Tissue factor pathway inhibitor
(1997) Novel Therapeutic Agents in Thrombosis and Thrombolysis, pp. 225-260. Cited 8 times.
Sasahara A, Loscalzo J, eds. New York: Marcel Dekker
Oostryck, R.; School of Biomedical Sciences, Curtin University of Technology, GPO Box U 1987, Perth, WA 6845, Australia; email:r.oostryck@info.curtin.edu.au
© Copyright 2006 Elsevier B.V., All rights reserved
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<meta content="Tissue factor pathway inhibitor (TFPI) is a recently 'rediscovered' inhibitor of tissue factor mediated coagulation that has a central role in the modern hypothesis of coagulation. The regulatory role of this inhibitor has redefined the classical extrinsic and intrinsic pathways of coagulation and helps to explain why haemophiliacs bleed. Comprehensive investigations have been performed during the last 15 years to elucidate the structure, distribution, function and physiological characteristics of TFPI. More recent work has focused on the therapeutic potential of TFPI as an antithrombotic agent. Augmentation of TFPI levels may provide treatment for thrombotic disorders such as disseminated intravascular coagulation and deep vein thrombosis. Full length and truncated forms of TFPI molecules are also being considered as antithrombotic agents. These have been used in a number of animal models with initial results demonstrating the alleviation of thrombotic tendencies. Trials are currently ongoing." name="DC.description" />
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<h1 class="ep_tm_pagetitle">Tissue factor pathway inhibitor: Regulator of the tissue factor pathway of coagulation and a future antithrombotic agent?</h1>
<p style="margin-bottom: 1em" class="not_ep_block"><span class="person_name">Adams, M.J.</span> and <span class="person_name">Oostryck, R.</span> (2000) <xhtml:em>Tissue factor pathway inhibitor: Regulator of the tissue factor pathway of coagulation and a future antithrombotic agent?</xhtml:em> Australian Journal of Medical Science, 21 (1). pp. 2-9. ISSN 1038-1643</p><p style="margin-bottom: 1em" class="not_ep_block"></p><table style="margin-bottom: 1em" class="not_ep_block"><tr><td valign="top" style="text-align:center"><a href="http://eprints.utas.edu.au/2357/1/Tissue_Factor.pdf"><img alt="[img]" src="http://eprints.utas.edu.au/style/images/fileicons/application_pdf.png" class="ep_doc_icon" border="0" /></a></td><td valign="top"><a href="http://eprints.utas.edu.au/2357/1/Tissue_Factor.pdf"><span class="ep_document_citation">PDF</span></a> - Full text restricted - Requires a PDF viewer<br />2062Kb</td><td><form method="get" accept-charset="utf-8" action="http://eprints.utas.edu.au/cgi/request_doc"><input accept-charset="utf-8" value="3015" name="docid" type="hidden" /><div class=""><input value="Request a copy" name="_action_null" class="ep_form_action_button" onclick="return EPJS_button_pushed( '_action_null' )" type="submit" /> </div></form></td></tr></table><p style="margin-bottom: 1em" class="not_ep_block">Official URL: <a href="http://www.aims.org.au/c/">http://www.aims.org.au/c/</a></p><div class="not_ep_block"><h2>Abstract</h2><p style="padding-bottom: 16px; text-align: left; margin: 1em auto 0em auto">Tissue factor pathway inhibitor (TFPI) is a recently 'rediscovered' inhibitor of tissue factor mediated coagulation that has a central role in the modern hypothesis of coagulation. The regulatory role of this inhibitor has redefined the classical extrinsic and intrinsic pathways of coagulation and helps to explain why haemophiliacs bleed. Comprehensive investigations have been performed during the last 15 years to elucidate the structure, distribution, function and physiological characteristics of TFPI. More recent work has focused on the therapeutic potential of TFPI as an antithrombotic agent. Augmentation of TFPI levels may provide treatment for thrombotic disorders such as disseminated intravascular coagulation and deep vein thrombosis. Full length and truncated forms of TFPI molecules are also being considered as antithrombotic agents. These have been used in a number of animal models with initial results demonstrating the alleviation of thrombotic tendencies. Trials are currently ongoing.</p></div><table style="margin-bottom: 1em" cellpadding="3" class="not_ep_block" border="0"><tr><th valign="top" class="ep_row">Item Type:</th><td valign="top" class="ep_row">Article</td></tr><tr><th valign="top" class="ep_row">Keywords:</th><td valign="top" class="ep_row">Antithrombotic agent; Coagulation; Thrombosis; Tissue factor; Tissue factor pathway inhibitor
</td></tr><tr><th valign="top" class="ep_row">Subjects:</th><td valign="top" class="ep_row"><a href="http://eprints.utas.edu.au/view/subjects/320000.html">320000 Medical and Health Sciences</a></td></tr><tr><th valign="top" class="ep_row">ID Code:</th><td valign="top" class="ep_row">2357</td></tr><tr><th valign="top" class="ep_row">Deposited By:</th><td valign="top" class="ep_row"><span class="ep_name_citation"><span class="person_name">Scholarly Publications Librarian</span></span></td></tr><tr><th valign="top" class="ep_row">Deposited On:</th><td valign="top" class="ep_row">02 Nov 2007 11:22</td></tr><tr><th valign="top" class="ep_row">Last Modified:</th><td valign="top" class="ep_row">09 Jan 2008 02:30</td></tr><tr><th valign="top" class="ep_row">ePrint Statistics:</th><td valign="top" class="ep_row"><a target="ePrintStats" href="/es/index.php?action=show_detail_eprint;id=2357;">View statistics for this ePrint</a></td></tr></table><p align="right">Repository Staff Only: <a href="http://eprints.utas.edu.au/cgi/users/home?screen=EPrint::View&eprintid=2357">item control page</a></p>
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