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<title>UTas ePrints - A role for the tissue factor pathway in the pathogenesis of the antiphospholipid syndrome</title>
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<meta content="Lean, Sim Yee" name="eprints.creators_name" />
<meta content="Adams, M.J." name="eprints.creators_name" />
<meta content="" name="eprints.creators_id" />
<meta content="Murray.Adams@utas.edu.au" name="eprints.creators_id" />
<meta content="article" name="eprints.type" />
<meta content="2007-11-15 01:28:18" name="eprints.datestamp" />
<meta content="2008-01-08 15:30:00" name="eprints.lastmod" />
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<meta content="A role for the tissue factor pathway in the pathogenesis
of the antiphospholipid syndrome" name="eprints.title" />
<meta content="pub" name="eprints.ispublished" />
<meta content="321008" name="eprints.subjects" />
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<meta content="Antiphospholipid antibodies; Antiphospholipid syndrome; Thrombosis; Tissue factor; Tissue factor pathway inhibitor" name="eprints.keywords" />
<meta content="The antiphospholipid syndrome (aPS) is a systemic autoimmune disorder that is characterised by
laboratory markers of antiphospholipid antibodies (aPL) as well as clinical manifestations such as arterial
and venous thrombosis, recurrent pregnancy loss and thrombocytopaenia. Although it is unclear precisely
what mechanism(s) lead to thrombosis in aPS, it is probable that the contribution of aPL such as anti-β-2-
glycoprotein-1 (anti-β2GP1) is signifi cant. Indeed, there is increasing evidence that aPL may interfere with
the tissue factor (TF) pathway of blood coagulation and its natural regulator tissue factor pathway inhibitor
(TFPI), thus contributing toward the development of thrombosis in aPS. This paper will therefore review
1) the TF pathway of blood coagulation and TFPI, 2) clinical and laboratory aspects of aPL and aPS,
and 3) interactions of aPL with the TF pathway, to highlight the potential signifi cance of these in the
pathogenesis of aPS." name="eprints.abstract" />
<meta content="2007-08" name="eprints.date" />
<meta content="published" name="eprints.date_type" />
<meta content="Australian Journal of Medical Science" name="eprints.publication" />
<meta content="28" name="eprints.volume" />
<meta content="3" name="eprints.number" />
<meta content="99-107" name="eprints.pagerange" />
<meta content="TRUE" name="eprints.refereed" />
<meta content="1038-1643" name="eprints.issn" />
<meta content="http://www.aims.org.au/c/" name="eprints.official_url" />
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<meta content="Lean, Sim Yee and Adams, M.J. (2007) A role for the tissue factor pathway in the pathogenesis of the antiphospholipid syndrome. Australian Journal of Medical Science, 28 (3). pp. 99-107. ISSN 1038-1643" name="eprints.citation" />
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<meta content="A role for the tissue factor pathway in the pathogenesis
of the antiphospholipid syndrome" name="DC.title" />
<meta content="Lean, Sim Yee" name="DC.creator" />
<meta content="Adams, M.J." name="DC.creator" />
<meta content="321008 Haematology" name="DC.subject" />
<meta content="The antiphospholipid syndrome (aPS) is a systemic autoimmune disorder that is characterised by
laboratory markers of antiphospholipid antibodies (aPL) as well as clinical manifestations such as arterial
and venous thrombosis, recurrent pregnancy loss and thrombocytopaenia. Although it is unclear precisely
what mechanism(s) lead to thrombosis in aPS, it is probable that the contribution of aPL such as anti-β-2-
glycoprotein-1 (anti-β2GP1) is signifi cant. Indeed, there is increasing evidence that aPL may interfere with
the tissue factor (TF) pathway of blood coagulation and its natural regulator tissue factor pathway inhibitor
(TFPI), thus contributing toward the development of thrombosis in aPS. This paper will therefore review
1) the TF pathway of blood coagulation and TFPI, 2) clinical and laboratory aspects of aPL and aPS,
and 3) interactions of aPL with the TF pathway, to highlight the potential signifi cance of these in the
pathogenesis of aPS." name="DC.description" />
<meta content="2007-08" name="DC.date" />
<meta content="Article" name="DC.type" />
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<h1 class="ep_tm_pagetitle">A role for the tissue factor pathway in the pathogenesis of the antiphospholipid syndrome</h1>
<p style="margin-bottom: 1em" class="not_ep_block"><span class="person_name">Lean, Sim Yee</span> and <span class="person_name">Adams, M.J.</span> (2007) <xhtml:em>A role for the tissue factor pathway in the pathogenesis of the antiphospholipid syndrome.</xhtml:em> Australian Journal of Medical Science, 28 (3). pp. 99-107. ISSN 1038-1643</p><p style="margin-bottom: 1em" class="not_ep_block"></p><table style="margin-bottom: 1em" class="not_ep_block"><tr><td valign="top" style="text-align:center"><a href="http://eprints.utas.edu.au/2442/1/Adams_and_Lean_2007.pdf"><img alt="[img]" src="http://eprints.utas.edu.au/style/images/fileicons/application_pdf.png" class="ep_doc_icon" border="0" /></a></td><td valign="top"><a href="http://eprints.utas.edu.au/2442/1/Adams_and_Lean_2007.pdf"><span class="ep_document_citation">PDF</span></a> - Full text restricted - Requires a PDF viewer<br />317Kb</td><td><form method="get" accept-charset="utf-8" action="http://eprints.utas.edu.au/cgi/request_doc"><input accept-charset="utf-8" value="3195" name="docid" type="hidden" /><div class=""><input value="Request a copy" name="_action_null" class="ep_form_action_button" onclick="return EPJS_button_pushed( '_action_null' )" type="submit" /> </div></form></td></tr></table><p style="margin-bottom: 1em" class="not_ep_block">Official URL: <a href="http://www.aims.org.au/c/">http://www.aims.org.au/c/</a></p><div class="not_ep_block"><h2>Abstract</h2><p style="padding-bottom: 16px; text-align: left; margin: 1em auto 0em auto">The antiphospholipid syndrome (aPS) is a systemic autoimmune disorder that is characterised by
laboratory markers of antiphospholipid antibodies (aPL) as well as clinical manifestations such as arterial
and venous thrombosis, recurrent pregnancy loss and thrombocytopaenia. Although it is unclear precisely
what mechanism(s) lead to thrombosis in aPS, it is probable that the contribution of aPL such as anti-β-2-
glycoprotein-1 (anti-β2GP1) is signifi cant. Indeed, there is increasing evidence that aPL may interfere with
the tissue factor (TF) pathway of blood coagulation and its natural regulator tissue factor pathway inhibitor
(TFPI), thus contributing toward the development of thrombosis in aPS. This paper will therefore review
1) the TF pathway of blood coagulation and TFPI, 2) clinical and laboratory aspects of aPL and aPS,
and 3) interactions of aPL with the TF pathway, to highlight the potential signifi cance of these in the
pathogenesis of aPS.</p></div><table style="margin-bottom: 1em" cellpadding="3" class="not_ep_block" border="0"><tr><th valign="top" class="ep_row">Item Type:</th><td valign="top" class="ep_row">Article</td></tr><tr><th valign="top" class="ep_row">Keywords:</th><td valign="top" class="ep_row">Antiphospholipid antibodies; Antiphospholipid syndrome; Thrombosis; Tissue factor; Tissue factor pathway inhibitor</td></tr><tr><th valign="top" class="ep_row">Subjects:</th><td valign="top" class="ep_row"><a href="http://eprints.utas.edu.au/view/subjects/321008.html">320000 Medical and Health Sciences > 321000 Clinical Sciences > 321008 Haematology</a></td></tr><tr><th valign="top" class="ep_row">ID Code:</th><td valign="top" class="ep_row">2442</td></tr><tr><th valign="top" class="ep_row">Deposited By:</th><td valign="top" class="ep_row"><span class="ep_name_citation"><span class="person_name">Dr Murray J Adams</span></span></td></tr><tr><th valign="top" class="ep_row">Deposited On:</th><td valign="top" class="ep_row">15 Nov 2007 12:28</td></tr><tr><th valign="top" class="ep_row">Last Modified:</th><td valign="top" class="ep_row">09 Jan 2008 02:30</td></tr><tr><th valign="top" class="ep_row">ePrint Statistics:</th><td valign="top" class="ep_row"><a target="ePrintStats" href="/es/index.php?action=show_detail_eprint;id=2442;">View statistics for this ePrint</a></td></tr></table><p align="right">Repository Staff Only: <a href="http://eprints.utas.edu.au/cgi/users/home?screen=EPrint::View&eprintid=2442">item control page</a></p>
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