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<meta content="Ding, Changhai" name="eprints.creators_name" />
<meta content="Cicuttini, Flavia" name="eprints.creators_name" />
<meta content="Scott, Fiona" name="eprints.creators_name" />
<meta content="Cooley, Helen" name="eprints.creators_name" />
<meta content="Boon, Catrina" name="eprints.creators_name" />
<meta content="Jones, Graeme" name="eprints.creators_name" />
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<meta content="Natural history of knee cartilage defects and factors affecting change." name="eprints.title" />
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<meta content="cartilage defects, risk factor, cartilage volume, bone area, osteoarthritis " name="eprints.keywords" />
<meta content="BACKGROUND: Knee cartilage defects may play an important role in early osteoarthritis, but little is known about their natural history. METHODS: Knee cartilage defect score (range, 0-4), cartilage volume, and bone surface area were determined using T1-weighted fat-saturated magnetic resonance imaging in 325 subjects (mean age, 45 years) at baseline and 2 years later. RESULTS: Thirty-three percent of the subjects had a worsening (>or=1-point increase) and 37% of the subjects had an improvement (>or=1-point decrease) in cartilage defect score in any knee compartment during 2.3 years. A worsening in cartilage defect score was significantly associated with female sex (odds ratio [OR], 3.09 and 3.64 in the medial and lateral tibiofemoral compartments) and baseline factors, including age (OR, 1.05 per year in the medial tibiofemoral compartment), body mass index (OR, 1.08 in the lateral tibiofemoral compartment), tibiofemoral osteophytes (OR, 6.22 and 6.04 per grade), tibial bone area (OR, 1.24 and 2.07 per square centimeter), and cartilage volume (OR, 2.91 and 1.71 per milliliter in the medial tibiofemoral and patellar compartments). An improvement in cartilage defect score had similar but reversed associations with these factors (except for sex), including a decrease in body mass index (OR, 1.23 in the medial tibiofemoral compartment). CONCLUSIONS: Knee cartilage defects are variable, and changes are associated with female sex, age, and body mass index. Increases are associated with baseline cartilage volume, bone size, and osteophytes, suggesting a role for these in the pathogenesis of cartilage defects. Interventions such as weight loss may improve knee cartilage defects.
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<meta content="2006-03-27" name="eprints.date" />
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<meta content="Archives of Internal Medicine" name="eprints.publication" />
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<meta content="1. Ding C, Garnero P, Cicuttini F, Scott F, Cooley H, Jones G. Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdown. Osteoarthritis Cartilage. 2005;13:198-205. FULL TEXT | ISI | PUBMED
2. Hjelle K, Solheim E, Strand T, Muri R, Brittberg M. Articular cartilage defects in 1,000 knee arthroscopies. Arthroscopy. 2002;18:730-734. PUBMED
3. Shelbourne KD, Jari S, Gray T. Outcome of untreated traumatic articular cartilage defects of the knee: a natural history study. J Bone Joint Surg Am. 2003;85(suppl 2):8-16. FREE FULL TEXT
4. Lefkoe TP, Trafton PG, Ehrlich MG, et al. An experimental model of femoral condylar defect leading to osteoarthrosis. J Orthop Trauma. 1993;7:458-467. ISI | PUBMED
5. Link TM, Steinbach LS, Ghosh S, et al. Osteoarthritis: MR imaging findings in different stages of disease and correlation with clinical findings. Radiology. 2003;226:373-381. FREE FULL TEXT
6. Boegard T, Rudling O, Petersson IF, Jonsson K. Correlation between radiographically diagnosed osteophytes and magnetic resonance detected cartilage defects in the tibiofemoral joint. Ann Rheum Dis. 1998;57:401-407. FREE FULL TEXT
7. Ding C, Cicuttini F, Scott F, Cooley H, Jones G. Association between age and knee structural change: a cross sectional MRI based study. Ann Rheum Dis. 2005;64:549-555. FREE FULL TEXT
8. Ding C, Cicuttini F, Scott F, Cooley H, Jones G. Knee structural alteration and BMI: a cross-sectional study. Obes Res. 2005;13:350-361. FREE FULL TEXT
9. Cicuttini F, Ding C, Wluka A, Davis S, Ebeling PR, Jones G. Association of cartilage defects with loss of knee cartilage in healthy, middle-age adults: a prospective study. Arthritis Rheum. 2005;52:2033-2039. FULL TEXT | ISI | PUBMED
10. Biswal S, Hastie T, Andriacchi TP, Bergman GA, Dillingham MF, Lang P. Risk factors for progressive cartilage loss in the knee: a longitudinal magnetic resonance imaging study in forty-three patients. Arthritis Rheum. 2002;46:2884-2892. FULL TEXT | ISI | PUBMED
11. McGibbon CA, Trahan CA. Measurement accuracy of focal cartilage defects from MRI and correlation of MRI graded lesions with histology: a preliminary study. Osteoarthritis Cartilage. 2003;11:483-493. FULL TEXT | ISI | PUBMED
12. Potter HG, Linklater JM, Allen AA, Hannafin JA, Haas SB. Magnetic resonance imaging of articular cartilage in the knee: an evaluation with use of fast-spin-echo imaging. J Bone Joint Surg Am. 1998;80:1276-1284. FREE FULL TEXT
13. Jones G, Ding C, Glisson M, Ma D, Cicuttini F. Knee articular cartilage development in children: a longitudinal study of the effect of gender, growth, body composition and physical activity. Pediatr Res. 2003;54:230-236. FREE FULL TEXT
14. Jones G, Ding C, Scott F, Glisson M, Cicuttini F. Early radiographic osteoarthritis is associated with substantial changes in cartilage volume and tibial bone surface area in both males and females. Osteoarthritis Cartilage. 2004;12:169-174. FULL TEXT | ISI | PUBMED
15. Jones G, Ding C, Scott F, Cicuttini F. Genetic mechanisms of knee osteoarthritis: a population-based case control study. Ann Rheum Dis. 2004;63:1255-1259. FREE FULL TEXT
16. Jones G, Glisson M, Hynes K, Cicuttini F. Sex and site differences in cartilage development: a possible explanation for variations in knee osteoarthritis in later life. Arthritis Rheum. 2000;43:2543-2548. FULL TEXT | ISI | PUBMED
17. Oliveria SA, Felson DT, Reed JI, Cirillo PA, Walker AM. Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization. Arthritis Rheum. 1995;38:1134-1141. ISI | PUBMED
18. Hart DJ, Doyle DV, Spector TD. Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women: the Chingford Study. Arthritis Rheum. 1999;42:17-24. FULL TEXT | ISI | PUBMED
19. Schouten JS, van den Ouweland FA, Valkenburg HA. A 12 year follow up study in the general population on prognostic factors of cartilage loss in osteoarthritis of the knee. Ann Rheum Dis. 1992;51:932-937. ABSTRACT
20. Ding C, Cicuttini F, Scott F, Glisson M, Jones G. Sex differences in knee cartilage volume in adults: role of body and bone size, age and physical activity. Rheumatology (Oxford). 2003;42:1317-1323. FULL TEXT | PUBMED
21. Wluka AE, Stuckey S, Snaddon J, Cicuttini FM. The determinants of change in tibial cartilage volume in osteoarthritic knees. Arthritis Rheum. 2002;46:2065-2072. FULL TEXT | ISI | PUBMED
22. Tessier JJ, Bowyer J, Brownrigg NJ, et al. Characterisation of the guinea pig model of osteoarthritis by in vivo three-dimensional magnetic resonance imaging. Osteoarthritis Cartilage. 2003;11:845-853. FULL TEXT | ISI | PUBMED
23. Pessis E, Drape JL, Ravaud P, Chevrot A, Dougados M, Ayral X. Assessment of progression in knee osteoarthritis: results of a 1 year study comparing arthroscopy and MRI. Osteoarthritis Cartilage. 2003;11:361-369. FULL TEXT | ISI | PUBMED
24. Miettinen OS. Theoretical Epidemiology: Principles of Occurrence Research in Medicine. New York, NY: John Wiley & Sons Inc; 1985.
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<meta content="Ding, Changhai and Cicuttini, Flavia and Scott, Fiona and Cooley, Helen and Boon, Catrina and Jones, Graeme (2006) Natural history of knee cartilage defects and factors affecting change. Archives of Internal Medicine, 166 (6). pp. 651-658." name="eprints.citation" />
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<meta content="BACKGROUND: Knee cartilage defects may play an important role in early osteoarthritis, but little is known about their natural history. METHODS: Knee cartilage defect score (range, 0-4), cartilage volume, and bone surface area were determined using T1-weighted fat-saturated magnetic resonance imaging in 325 subjects (mean age, 45 years) at baseline and 2 years later. RESULTS: Thirty-three percent of the subjects had a worsening (>or=1-point increase) and 37% of the subjects had an improvement (>or=1-point decrease) in cartilage defect score in any knee compartment during 2.3 years. A worsening in cartilage defect score was significantly associated with female sex (odds ratio [OR], 3.09 and 3.64 in the medial and lateral tibiofemoral compartments) and baseline factors, including age (OR, 1.05 per year in the medial tibiofemoral compartment), body mass index (OR, 1.08 in the lateral tibiofemoral compartment), tibiofemoral osteophytes (OR, 6.22 and 6.04 per grade), tibial bone area (OR, 1.24 and 2.07 per square centimeter), and cartilage volume (OR, 2.91 and 1.71 per milliliter in the medial tibiofemoral and patellar compartments). An improvement in cartilage defect score had similar but reversed associations with these factors (except for sex), including a decrease in body mass index (OR, 1.23 in the medial tibiofemoral compartment). CONCLUSIONS: Knee cartilage defects are variable, and changes are associated with female sex, age, and body mass index. Increases are associated with baseline cartilage volume, bone size, and osteophytes, suggesting a role for these in the pathogenesis of cartilage defects. Interventions such as weight loss may improve knee cartilage defects.
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<h1 class="ep_tm_pagetitle">Natural history of knee cartilage defects and factors affecting change.</h1>
<p style="margin-bottom: 1em" class="not_ep_block"><span class="person_name">Ding, Changhai</span> and <span class="person_name">Cicuttini, Flavia</span> and <span class="person_name">Scott, Fiona</span> and <span class="person_name">Cooley, Helen</span> and <span class="person_name">Boon, Catrina</span> and <span class="person_name">Jones, Graeme</span> (2006) <xhtml:em>Natural history of knee cartilage defects and factors affecting change.</xhtml:em> Archives of Internal Medicine, 166 (6). pp. 651-658.</p><p style="margin-bottom: 1em" class="not_ep_block"></p><table style="margin-bottom: 1em" class="not_ep_block"><tr><td valign="top" style="text-align:center"><a href="http://eprints.utas.edu.au/849/1/Archives.pdf"><img alt="[img]" src="http://eprints.utas.edu.au/style/images/fileicons/application_pdf.png" class="ep_doc_icon" border="0" /></a></td><td valign="top"><a href="http://eprints.utas.edu.au/849/1/Archives.pdf"><span class="ep_document_citation">PDF</span></a> - Full text restricted - Requires a PDF viewer<br />254Kb</td></tr></table><p style="margin-bottom: 1em" class="not_ep_block">Official URL: <a href="http://archinte.ama-assn.org/cgi/content/full/166/6/651">http://archinte.ama-assn.org/cgi/content/full/166/6/651</a></p><div class="not_ep_block"><h2>Abstract</h2><p style="padding-bottom: 16px; text-align: left; margin: 1em auto 0em auto">BACKGROUND: Knee cartilage defects may play an important role in early osteoarthritis, but little is known about their natural history. METHODS: Knee cartilage defect score (range, 0-4), cartilage volume, and bone surface area were determined using T1-weighted fat-saturated magnetic resonance imaging in 325 subjects (mean age, 45 years) at baseline and 2 years later. RESULTS: Thirty-three percent of the subjects had a worsening (>or=1-point increase) and 37% of the subjects had an improvement (>or=1-point decrease) in cartilage defect score in any knee compartment during 2.3 years. A worsening in cartilage defect score was significantly associated with female sex (odds ratio [OR], 3.09 and 3.64 in the medial and lateral tibiofemoral compartments) and baseline factors, including age (OR, 1.05 per year in the medial tibiofemoral compartment), body mass index (OR, 1.08 in the lateral tibiofemoral compartment), tibiofemoral osteophytes (OR, 6.22 and 6.04 per grade), tibial bone area (OR, 1.24 and 2.07 per square centimeter), and cartilage volume (OR, 2.91 and 1.71 per milliliter in the medial tibiofemoral and patellar compartments). An improvement in cartilage defect score had similar but reversed associations with these factors (except for sex), including a decrease in body mass index (OR, 1.23 in the medial tibiofemoral compartment). CONCLUSIONS: Knee cartilage defects are variable, and changes are associated with female sex, age, and body mass index. Increases are associated with baseline cartilage volume, bone size, and osteophytes, suggesting a role for these in the pathogenesis of cartilage defects. Interventions such as weight loss may improve knee cartilage defects.
</p></div><table style="margin-bottom: 1em" cellpadding="3" class="not_ep_block" border="0"><tr><th valign="top" class="ep_row">Item Type:</th><td valign="top" class="ep_row">Article</td></tr><tr><th valign="top" class="ep_row">Keywords:</th><td valign="top" class="ep_row">cartilage defects, risk factor, cartilage volume, bone area, osteoarthritis </td></tr><tr><th valign="top" class="ep_row">Subjects:</th><td valign="top" class="ep_row"><a href="http://eprints.utas.edu.au/view/subjects/321028.html">320000 Medical and Health Sciences > 321000 Clinical Sciences > 321028 Rheumatology and Arthritis</a></td></tr><tr><th valign="top" class="ep_row">ID Code:</th><td valign="top" class="ep_row">849</td></tr><tr><th valign="top" class="ep_row">Deposited By:</th><td valign="top" class="ep_row"><span class="ep_name_citation"><span class="person_name">Dr Changhai / C Ding</span></span></td></tr><tr><th valign="top" class="ep_row">Deposited On:</th><td valign="top" class="ep_row">19 Mar 2007</td></tr><tr><th valign="top" class="ep_row">Last Modified:</th><td valign="top" class="ep_row">09 Jan 2008 02:30</td></tr><tr><th valign="top" class="ep_row">ePrint Statistics:</th><td valign="top" class="ep_row"><a target="ePrintStats" href="/es/index.php?action=show_detail_eprint;id=849;">View statistics for this ePrint</a></td></tr></table><p align="right">Repository Staff Only: <a href="http://eprints.utas.edu.au/cgi/users/home?screen=EPrint::View&eprintid=849">item control page</a></p>
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