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<title>UTas ePrints - Knee meniscal extrusion in a largely non-osteoarthritic cohort: Association with a higher loss of cartilage volume</title>
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<meta content="Ding, Changhai" name="eprints.creators_name" />
<meta content="Martel-Pelletier, Johanne" name="eprints.creators_name" />
<meta content="Pelletier, Jean-Pierre" name="eprints.creators_name" />
<meta content="Abram, Francois" name="eprints.creators_name" />
<meta content="Raynauld, Jean-Pierre" name="eprints.creators_name" />
<meta content="Cicuttini, Flavia" name="eprints.creators_name" />
<meta content="Jones, Graeme" name="eprints.creators_name" />
<meta content="chding@utas.edu.au" name="eprints.creators_id" />
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<meta content="2007-03-30" name="eprints.datestamp" />
<meta content="2008-01-08 15:30:00" name="eprints.lastmod" />
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<meta content="Knee meniscal extrusion in a largely non-osteoarthritic cohort: Association with a higher loss of cartilage volume" name="eprints.title" />
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<meta content="321028" name="eprints.subjects" />
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<meta content="extrusion, risk factor, cartilage loss, bone area, osteoarthritis" name="eprints.keywords" />
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<meta content="ABSTRACT: We conducted a longitudinal study (duration 2 years), including 294 individuals (mean age 45 years, 58% female), in order to examine associations between meniscal extrusion, knee structure, radiographic changes and risk factors for osteoarthritis (OA) in a largely non-osteoarthritic cohort. Meniscal extrusion, tibiofemoral cartilage defect score and cartilage volume, and tibial plateau bone area were determined using T1-weighted fat-saturated magnetic resonance imaging. At baseline the presence of medial meniscal extrusion was significantly associated with body mass index (odds ratio [OR] per kg/m2 = 1.13, 95% confidence interval [CI] = 1.02-1.25), past knee injury (positive versus negative history: OR = 3.73, 95% CI = 1.16-11.97), medial tibial bone area (OR per cm2 = 1.37, 95% CI = 1.02-1.85), and osteophytes (OR per grade = 4.89, 95% CI = 1.59-15.02). Two-year longitudinal data revealed that medial meniscal extrusion at baseline was associated with a greater rate of loss of medial tibiofemoral cartilage volume (extrusion versus no extrusion: -1.4%/year; P < 0.05) and greater risk for increased medial femoral cartilage defects (OR = 2.59, 95% CI = 1.14-5.86) and lateral tibial cartilage defects (OR = 2.64, 95% CI = 1.03-6.76). However, the latter two associations became nonsignificant after adjustment for tibial bone area and osteophytes. This study suggests that increasing body mass index and bone size, past knee injury, and osteophytes may be causally related to meniscal extrusion. Most importantly, meniscal extrusion at baseline is associated with greater loss of knee cartilage over 2 years, and this seems to be mediated mostly by subchondral bone changes, suggesting extrusion represents one pathway between bone expansion and cartilage loss.
" name="eprints.abstract" />
<meta content="2007-03-02" name="eprints.date" />
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<meta content="Arthritis Research & Therapy" name="eprints.publication" />
<meta content="9" name="eprints.volume" />
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<meta content="R21" name="eprints.pagerange" />
<meta content="10.1186/ar2132" name="eprints.id_number" />
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<meta content="Ding, Changhai and Martel-Pelletier, Johanne and Pelletier, Jean-Pierre and Abram, Francois and Raynauld, Jean-Pierre and Cicuttini, Flavia and Jones, Graeme (2007) Knee meniscal extrusion in a largely non-osteoarthritic cohort: Association with a higher loss of cartilage volume. Arthritis Research & Therapy, 9 (2). R21. ISSN 1465-9913" name="eprints.citation" />
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<meta content="Knee meniscal extrusion in a largely non-osteoarthritic cohort: Association with a higher loss of cartilage volume" name="DC.title" />
<meta content="Ding, Changhai" name="DC.creator" />
<meta content="Martel-Pelletier, Johanne" name="DC.creator" />
<meta content="Pelletier, Jean-Pierre" name="DC.creator" />
<meta content="Abram, Francois" name="DC.creator" />
<meta content="Raynauld, Jean-Pierre" name="DC.creator" />
<meta content="Cicuttini, Flavia" name="DC.creator" />
<meta content="Jones, Graeme" name="DC.creator" />
<meta content="321028 Rheumatology and Arthritis" name="DC.subject" />
<meta content="ABSTRACT: We conducted a longitudinal study (duration 2 years), including 294 individuals (mean age 45 years, 58% female), in order to examine associations between meniscal extrusion, knee structure, radiographic changes and risk factors for osteoarthritis (OA) in a largely non-osteoarthritic cohort. Meniscal extrusion, tibiofemoral cartilage defect score and cartilage volume, and tibial plateau bone area were determined using T1-weighted fat-saturated magnetic resonance imaging. At baseline the presence of medial meniscal extrusion was significantly associated with body mass index (odds ratio [OR] per kg/m2 = 1.13, 95% confidence interval [CI] = 1.02-1.25), past knee injury (positive versus negative history: OR = 3.73, 95% CI = 1.16-11.97), medial tibial bone area (OR per cm2 = 1.37, 95% CI = 1.02-1.85), and osteophytes (OR per grade = 4.89, 95% CI = 1.59-15.02). Two-year longitudinal data revealed that medial meniscal extrusion at baseline was associated with a greater rate of loss of medial tibiofemoral cartilage volume (extrusion versus no extrusion: -1.4%/year; P < 0.05) and greater risk for increased medial femoral cartilage defects (OR = 2.59, 95% CI = 1.14-5.86) and lateral tibial cartilage defects (OR = 2.64, 95% CI = 1.03-6.76). However, the latter two associations became nonsignificant after adjustment for tibial bone area and osteophytes. This study suggests that increasing body mass index and bone size, past knee injury, and osteophytes may be causally related to meniscal extrusion. Most importantly, meniscal extrusion at baseline is associated with greater loss of knee cartilage over 2 years, and this seems to be mediated mostly by subchondral bone changes, suggesting extrusion represents one pathway between bone expansion and cartilage loss.
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<h1 class="ep_tm_pagetitle">Knee meniscal extrusion in a largely non-osteoarthritic cohort: Association with a higher loss of cartilage volume</h1>
<p style="margin-bottom: 1em" class="not_ep_block"><span class="person_name">Ding, Changhai</span> and <span class="person_name">Martel-Pelletier, Johanne</span> and <span class="person_name">Pelletier, Jean-Pierre</span> and <span class="person_name">Abram, Francois</span> and <span class="person_name">Raynauld, Jean-Pierre</span> and <span class="person_name">Cicuttini, Flavia</span> and <span class="person_name">Jones, Graeme</span> (2007) <xhtml:em>Knee meniscal extrusion in a largely non-osteoarthritic cohort: Association with a higher loss of cartilage volume.</xhtml:em> Arthritis Research & Therapy, 9 (2). R21. ISSN 1465-9913</p><p style="margin-bottom: 1em" class="not_ep_block"></p><table style="margin-bottom: 1em" class="not_ep_block"><tr><td valign="top" style="text-align:center"><a onmouseover="EPJS_ShowPreview( event, 'doc_preview_878' );" href="http://eprints.utas.edu.au/875/1/ar2132.pdf" onmouseout="EPJS_HidePreview( event, 'doc_preview_878' );"><img alt="[img]" src="http://eprints.utas.edu.au/style/images/fileicons/application_pdf.png" class="ep_doc_icon" border="0" /></a><div class="ep_preview" id="doc_preview_878"><table><tr><td><img alt="" src="http://eprints.utas.edu.au/875/thumbnails/1/preview.png" class="ep_preview_image" border="0" /><div class="ep_preview_title">Preview</div></td></tr></table></div></td><td valign="top"><a href="http://eprints.utas.edu.au/875/1/ar2132.pdf"><span class="ep_document_citation">PDF</span></a> - Requires a PDF viewer<br />242Kb</td></tr></table><p style="margin-bottom: 1em" class="not_ep_block">Official URL: <a href="http://arthritis-research.com/content/9/2/R21">http://arthritis-research.com/content/9/2/R21</a></p><div class="not_ep_block"><h2>Abstract</h2><p style="padding-bottom: 16px; text-align: left; margin: 1em auto 0em auto">ABSTRACT: We conducted a longitudinal study (duration 2 years), including 294 individuals (mean age 45 years, 58% female), in order to examine associations between meniscal extrusion, knee structure, radiographic changes and risk factors for osteoarthritis (OA) in a largely non-osteoarthritic cohort. Meniscal extrusion, tibiofemoral cartilage defect score and cartilage volume, and tibial plateau bone area were determined using T1-weighted fat-saturated magnetic resonance imaging. At baseline the presence of medial meniscal extrusion was significantly associated with body mass index (odds ratio [OR] per kg/m2 = 1.13, 95% confidence interval [CI] = 1.02-1.25), past knee injury (positive versus negative history: OR = 3.73, 95% CI = 1.16-11.97), medial tibial bone area (OR per cm2 = 1.37, 95% CI = 1.02-1.85), and osteophytes (OR per grade = 4.89, 95% CI = 1.59-15.02). Two-year longitudinal data revealed that medial meniscal extrusion at baseline was associated with a greater rate of loss of medial tibiofemoral cartilage volume (extrusion versus no extrusion: -1.4%/year; P < 0.05) and greater risk for increased medial femoral cartilage defects (OR = 2.59, 95% CI = 1.14-5.86) and lateral tibial cartilage defects (OR = 2.64, 95% CI = 1.03-6.76). However, the latter two associations became nonsignificant after adjustment for tibial bone area and osteophytes. This study suggests that increasing body mass index and bone size, past knee injury, and osteophytes may be causally related to meniscal extrusion. Most importantly, meniscal extrusion at baseline is associated with greater loss of knee cartilage over 2 years, and this seems to be mediated mostly by subchondral bone changes, suggesting extrusion represents one pathway between bone expansion and cartilage loss.
</p></div><table style="margin-bottom: 1em" cellpadding="3" class="not_ep_block" border="0"><tr><th valign="top" class="ep_row">Item Type:</th><td valign="top" class="ep_row">Article</td></tr><tr><th valign="top" class="ep_row">Additional Information:</th><td valign="top" class="ep_row">http://arthritis-research.com/content/9/2/R21
</td></tr><tr><th valign="top" class="ep_row">Keywords:</th><td valign="top" class="ep_row">extrusion, risk factor, cartilage loss, bone area, osteoarthritis</td></tr><tr><th valign="top" class="ep_row">Subjects:</th><td valign="top" class="ep_row"><a href="http://eprints.utas.edu.au/view/subjects/321028.html">320000 Medical and Health Sciences > 321000 Clinical Sciences > 321028 Rheumatology and Arthritis</a></td></tr><tr><th valign="top" class="ep_row">ID Code:</th><td valign="top" class="ep_row">875</td></tr><tr><th valign="top" class="ep_row">Deposited By:</th><td valign="top" class="ep_row"><span class="ep_name_citation"><span class="person_name">Dr Changhai / C Ding</span></span></td></tr><tr><th valign="top" class="ep_row">Deposited On:</th><td valign="top" class="ep_row">30 Mar 2007</td></tr><tr><th valign="top" class="ep_row">Last Modified:</th><td valign="top" class="ep_row">09 Jan 2008 02:30</td></tr><tr><th valign="top" class="ep_row">ePrint Statistics:</th><td valign="top" class="ep_row"><a target="ePrintStats" href="/es/index.php?action=show_detail_eprint;id=875;">View statistics for this ePrint</a></td></tr></table><p align="right">Repository Staff Only: <a href="http://eprints.utas.edu.au/cgi/users/home?screen=EPrint::View&eprintid=875">item control page</a></p>
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