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<title>UTas ePrints - Reduced [125 I- Bolton Hunter Substance P Binding (NK1 Receptors) in the Basal Forebrain Nuclei of Aged Rats</title>
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<meta content="Maguire, C.M." name="eprints.creators_name" />
<meta content="Geraghty, D.P." name="eprints.creators_name" />
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<meta content="D.Geraghty@utas.edu.au" name="eprints.creators_id" />
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<meta content="2007-10-23 23:47:13" name="eprints.datestamp" />
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<meta content="Reduced [125 I- Bolton Hunter Substance P Binding (NK1 Receptors) in the Basal Forebrain Nuclei of Aged Rats" name="eprints.title" />
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<meta content="1. Quantitative autoradiography and homogenate radioligand
binding of [
125
I]-Bolton Hunter substance P ([
125
I]-BHSP)
were used to compare brain NK
1
receptors in young (2 months)
and aged (18–20 months) rats.
2. The
autoradiographic
distribution
and
density
of
[
125
I]-BHSP binding sites was similar in all cortical regions of
young and aged rats. In contrast, the density of [
125
I]-BHSP
binding sites was significantly (
P
< 0.05) lower in the basal
forebrain nuclei (intermediate part of the lateral septal nuclei,
medial septal nucleus and horizontal and vertical nuclei of the
diagonal band) of aged rats. In all other brain regions
examined, binding densities were almost identical in young and
aged rats.
3. Because a population of NK
1
receptors ([
125
I]-BHSP
binding sites) in the basal forebrain nuclei is associated with
cholinergic neurons, the decrease in NK
1
receptors in aged rats
may reflect degeneration of cholinergic neurons and contribute
to the motor and cognitive deficiencies that occur with ageing.
Key words: ageing, autoradiography, basal forebrain, NK
1
receptor, tachykinin." name="eprints.abstract" />
<meta content="2002" name="eprints.date" />
<meta content="Clinical and Experimental Pharmacology and Physiology" name="eprints.publication" />
<meta content="29" name="eprints.volume" />
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<meta content="10.1046/j.1440-1681.2002.03781.x" name="eprints.id_number" />
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<meta content="Kowall NW, Quigley BJ, Krause JE, Lu F, Kosofsky BE, Ferrante RJ.
Substance P and substance P receptor histochemistry in human neurodegenerative
disease. Regul. Pept. 1993; 46: 174–85.
2. Volpi R, Caffarra P, Scaglioni A et al. Age related changes in the
contents of neuropeptides in the rat brain and pituitary. Neurobiol.
Aging 1993; 14: 529–34.
3. Hasenöhrl RU, Frisch C, Nikolaus S, Huston JP. Chronic administration
of neurokinin substance P improves maze performance in aged
Rattus norvegicus. Behav. Neural Biol. 1994; 62: 110–20.
4. Kowall NW, Beal MF, Busciglio J, Duffy LK, Yankner BA. An in vivo
model for the neurodegenerative effects of -amyloid protein and
protection by substance P. Proc. Natl Acad. Sci. USA 1991;
88: 7247–51.
5. Sandberg PR, Emerich DF, Aebischer P et al. Substance P containing
polymer implants protect against striatal excitotoxicity. Brain Res.
1993; 628: 327–9.
6. Mattioli R, Schwarting RKW, Huston JP. Recovery from unilateral
6-hydroxydopamine lesion of substantia nigra promoted by the neurotachykinin
substance P1−11. Neuroscience 1992; 48: 595–605.
7. Dam T-V, Escher E, Quirion R. Evidence for the existence of three
classes of neurokinin receptors in brain. Differential ontogeny of
neurokinin-1, neurokinin-2 and neurokinin-3 binding sites in rat
cerebral cortex. Brain Res. 1988; 453: 372–6.
8. Maguire CM, Geraghty DP. Comparison of [125I]-Bolton Hunter
substance P binding in young and aged rat spinal cord. Brain Res.
1998; 786: 263–6.
9. Mazzone SB, Hinrichsen CF, Geraghty DP. Substance P receptors in
the brain stem respiratory centres of the rat. Regulation of NK1
receptors by hypoxia. J. Pharmacol. Exp. Ther. 1997; 282: 1547–56.
10. Mazzone SB, Geraghty DP. Altered respiratory response to substance
P and reduced NK1 receptor binding in the nucleus of the solitary tract
of aged rats. Brain Res. 1999; 826: 139–42.
11. Munson PJ, Robard D. LIGAND. A versatile computerized approach
for the characterization of ligand-binding systems. Anal. Biochem.
1980; 107: 220–39.
12. Jones RSG, Olpe HR. Multiple changes in the sensitivity of cingulate
cortical neurones to putative neurotransmitters in aging rats: Substance
P, acetylcholine and noradrenaline. Neurosci. Lett. 1984; 50: 31–6.
13. Parent A, Rowe W, Meaney MJ, Quirion R. Increased production of
inositol phosphates and diacylglycerol in aged cognitively impaired
rats after stimulation of muscarinic, metabotropic glutamate and
endothelin receptors. J. Pharmacol. Exp. Ther. 1995; 272: 1110–16.
14. Gerfen CR. Substance P (neurokinin-1) receptor mRNA is selectively
expressed in cholinergic neurons in the striatum and basal forebrain.
Brain Res. 1991; 556: 165–70.
15. Nakaya Y, Kaeko T, Shigemoto R, Nakanishi S, Mizuno N. Immunohistochemical
localization of substance P receptor in the central
nervous system of the adult rat. J. Comp. Neurol. 1994; 347: 249–74.
16. Hasenöhrl RU, Gerhardt P, Huston JP. Positively reinforcing effects of
the neurokinin substance P in the basal forebrain: Mediation by
its C-terminal sequence. Exp. Neurol. 1990; 115: 282–91.
17. Dunnet S. Cholinergic grafts, memory and aging. Trends Neurosci.
1991; 14: 371–6.
18. Yanker BA, Duffy LK, Kirschner DA. Neurotrophic and neurotoxic
effects of amyloid beta protein: Reversal by tachykinin neuropeptides.
Science 1990; 250: 279–82.
19. Saransaari P, Oja SS. Dizocilpine binding to cerebral cortical
membranes from developing and aging mice. Mech. Aging Dev. 1995;
85: 171–81.
20. Stoessl AJ, Polanski E, Frydeyszak H. Effects of aging on tachykinin
function in the basal ganglia. Brain Res. 1993; 632: 21–8." name="eprints.referencetext" />
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<meta content="Geraghty, D.P." name="DC.creator" />
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<meta content="1. Quantitative autoradiography and homogenate radioligand
binding of [
125
I]-Bolton Hunter substance P ([
125
I]-BHSP)
were used to compare brain NK
1
receptors in young (2 months)
and aged (18–20 months) rats.
2. The
autoradiographic
distribution
and
density
of
[
125
I]-BHSP binding sites was similar in all cortical regions of
young and aged rats. In contrast, the density of [
125
I]-BHSP
binding sites was significantly (
P
< 0.05) lower in the basal
forebrain nuclei (intermediate part of the lateral septal nuclei,
medial septal nucleus and horizontal and vertical nuclei of the
diagonal band) of aged rats. In all other brain regions
examined, binding densities were almost identical in young and
aged rats.
3. Because a population of NK
1
receptors ([
125
I]-BHSP
binding sites) in the basal forebrain nuclei is associated with
cholinergic neurons, the decrease in NK
1
receptors in aged rats
may reflect degeneration of cholinergic neurons and contribute
to the motor and cognitive deficiencies that occur with ageing.
Key words: ageing, autoradiography, basal forebrain, NK
1
receptor, tachykinin." name="DC.description" />
<meta content="2002" name="DC.date" />
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<h1 class="ep_tm_pagetitle">Reduced [125 I- Bolton Hunter Substance P Binding (NK1 Receptors) in the Basal Forebrain Nuclei of Aged Rats</h1>
<p style="margin-bottom: 1em" class="not_ep_block"><span class="person_name">Maguire, C.M.</span> and <span class="person_name">Geraghty, D.P.</span> (2002) <xhtml:em>Reduced [125 I- Bolton Hunter Substance P Binding (NK1 Receptors) in the Basal Forebrain Nuclei of Aged Rats.</xhtml:em> Clinical and Experimental Pharmacology and Physiology, 29 . pp. 1112-1115. ISSN 1440-1681</p><p style="margin-bottom: 1em" class="not_ep_block"></p><table style="margin-bottom: 1em" class="not_ep_block"><tr><td valign="top" style="text-align:center"><a href="http://eprints.utas.edu.au/2324/1/ReducedBoltonhunter.pdf"><img alt="[img]" src="http://eprints.utas.edu.au/style/images/fileicons/application_pdf.png" class="ep_doc_icon" border="0" /></a></td><td valign="top"><a href="http://eprints.utas.edu.au/2324/1/ReducedBoltonhunter.pdf"><span class="ep_document_citation">PDF</span></a> - Full text restricted - Requires a PDF viewer<br />991Kb</td><td><form method="get" accept-charset="utf-8" action="http://eprints.utas.edu.au/cgi/request_doc"><input accept-charset="utf-8" value="2978" name="docid" type="hidden" /><div class=""><input value="Request a copy" name="_action_null" class="ep_form_action_button" onclick="return EPJS_button_pushed( '_action_null' )" type="submit" /> </div></form></td></tr></table><p style="margin-bottom: 1em" class="not_ep_block">Official URL: <a href="http://dx.doi.org/10.1046/j.1440-1681.2002.03781.x">http://dx.doi.org/10.1046/j.1440-1681.2002.03781.x</a></p><div class="not_ep_block"><h2>Abstract</h2><p style="padding-bottom: 16px; text-align: left; margin: 1em auto 0em auto">1. Quantitative autoradiography and homogenate radioligand
binding of [
125
I]-Bolton Hunter substance P ([
125
I]-BHSP)
were used to compare brain NK
1
receptors in young (2 months)
and aged (18–20 months) rats.
2. The
autoradiographic
distribution
and
density
of
[
125
I]-BHSP binding sites was similar in all cortical regions of
young and aged rats. In contrast, the density of [
125
I]-BHSP
binding sites was significantly (
P
< 0.05) lower in the basal
forebrain nuclei (intermediate part of the lateral septal nuclei,
medial septal nucleus and horizontal and vertical nuclei of the
diagonal band) of aged rats. In all other brain regions
examined, binding densities were almost identical in young and
aged rats.
3. Because a population of NK
1
receptors ([
125
I]-BHSP
binding sites) in the basal forebrain nuclei is associated with
cholinergic neurons, the decrease in NK
1
receptors in aged rats
may reflect degeneration of cholinergic neurons and contribute
to the motor and cognitive deficiencies that occur with ageing.
Key words: ageing, autoradiography, basal forebrain, NK
1
receptor, tachykinin.</p></div><table style="margin-bottom: 1em" cellpadding="3" class="not_ep_block" border="0"><tr><th valign="top" class="ep_row">Item Type:</th><td valign="top" class="ep_row">Article</td></tr><tr><th valign="top" class="ep_row">Additional Information:</th><td valign="top" class="ep_row">The definitive version is available at www.blackwell-synergy.com</td></tr><tr><th valign="top" class="ep_row">Subjects:</th><td valign="top" class="ep_row"><a href="http://eprints.utas.edu.au/view/subjects/380103.html">380000 Behavioural and Cognitive Sciences > 380100 Psychology > 380103 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)</a><br /><a href="http://eprints.utas.edu.au/view/subjects/380100.html">380000 Behavioural and Cognitive Sciences > 380100 Psychology</a></td></tr><tr><th valign="top" class="ep_row">ID Code:</th><td valign="top" class="ep_row">2324</td></tr><tr><th valign="top" class="ep_row">Deposited By:</th><td valign="top" class="ep_row"><span class="ep_name_citation"><span class="person_name">Scholarly Publications Librarian</span></span></td></tr><tr><th valign="top" class="ep_row">Deposited On:</th><td valign="top" class="ep_row">24 Oct 2007 10:47</td></tr><tr><th valign="top" class="ep_row">Last Modified:</th><td valign="top" class="ep_row">09 Jan 2008 02:30</td></tr><tr><th valign="top" class="ep_row">ePrint Statistics:</th><td valign="top" class="ep_row"><a target="ePrintStats" href="/es/index.php?action=show_detail_eprint;id=2324;">View statistics for this ePrint</a></td></tr></table><p align="right">Repository Staff Only: <a href="http://eprints.utas.edu.au/cgi/users/home?screen=EPrint::View&eprintid=2324">item control page</a></p>
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