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    <title>UTas ePrints - Further investigations of lupus anticoagulant interference in a functional assay for tissue factor pathway inhibitor</title>
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    <meta content="Adams, M.J." name="eprints.creators_name" />
<meta content="Oostryck, R." name="eprints.creators_name" />
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<meta content="Tissue factor pathway inhibitor (TFPI) is a natural inhibitor that regulates the initiation of
coagulation by inhibiting tissue factor - activated factor VII (TF- FVIIa) in the presence of
activated factor X (FXa) (1). Although the precise role of TFPI in haemostasis is yet to be
determined, it's ability to inhibit TF - FVIla in the presence of FXa suggests that is does have an
important physiological significance.
TFPI levels have been reported to be normal in a variety of clinical conditions, including patients
with lupus anticoagulants (2,3). Lupus anticoagulants (LA) are acquired inhibitors, generally
considered to be immunoglobulins, that interfere with in vitro phospholipid dependent
coagulation tests (43). There is current interest in LA due to the associated thrombotic
complications as seen in increased risk for venous and arterial thrombosis as well as pregnancy
complications (6). We have previously reported decreased functional levels of TFPI in plasma
containing LA using a fluid phase assay, but normal levels with a binding assay (7). These low
levels of TFPI were shown to be corrected with the addition of excess TF (7).
As a continuation of this study, we again assessed TFPI levels in LA plasma using the same
fluid assay. The effect of using three different sources of tissue factor (recombinant, human
brain and rabbit brain thromboplastins) in the TFPI assay was examined. Of most significance
was the apparent correction of TFPI values as thromboplastin levels increased
" name="eprints.abstract" />
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<meta content="1. Broze, G.J., Warren, L.A., Novoyny,W.F., Higuchi, D.A., Girard, J.J., and
Miletich,J.P. The lipoprotein-associated coagulation inhibitor that inhibits the factor VII tissue
factor complex also inhibits factor Xa: insight into its possible mechanism of action.
Blood 71, 335-343, 1988.
2. Bajaj, M.S., Rana, S.V., Wysolmerski,R.B., and Bajaj, S.B. Inhibition of the
FVIIa-tissue complexis reduced in patients with disseminated intravascular coagulation but not
in patients with severe hepatocellular disease.J. Clin.Invest 79, 1874-1878,1987.
3. Jacobsen, E.M., Sandset, P.M., and Wisloff, F. Lupus anticoagulant and a
functional assay for tissue factor pathway inhibitor. Thrombosis Research 83,339-340, 1996.
4. McNeil, H.P., Chesterman,C.N., and Krilis, S.A. Anticardiolipin antibodies and
lupus anticoagulant comprise separate antibody subgroup swith different phospholipid binding
characteristics. Br. J. Haem 73, 506-513, 1989.
5. Triplett, D.A. Antiphospholipid-protein antibodies: laboratory detection and clinical
relevance. Thrombosis Research 78, 1-31,1995.
6. Triplett,D.A. Protean clinical presentation of antiphospholipid-protein antibodies(APA).
Thromb. Haemost. 74,329-337, 1995.
7. Adams,M.J., Dunstan,R.A., and Oostyck,R. Interference by lupus anticoagulant
in a functional assay for tissue factor pathway inhibitor. Thrombosis Research 80, 435-440,
1995.
8. Sandset, P.M., Larsen, M.L., Abildgaard, U., Lindahl, A.K., and
Odegaard,O.R. Chromogenic substrate assay of extrinsic pathway inhibitor(EPI): levels in
the normal population and relation to cholesterol. Blood Coagulation and Fibrinolysis 2, 425-
433, 1991.
9. Exner, T., Triplett, D.A., and Taberner, D. Guidelines for testing and revised
criteriafor lupus anticoagulants. Thromb. Haemost. 65, 320-322,1991.
10.Hjort,P.F. Intermediate reactions in the coagulation of blood with tissue thromboplastin.
Scand. J. Clin. Lab. Invest.9, 1-173,1957.
11.Nemerson,Y. Characterisation and lipid requirements of coagulant proteins extracted
from lung and brain. J. Clin. Invest.48,332-337, 1969.
12. Arnout, J., Vanrusselt, M., Huybrechts, E., and Vermylen, J.
Optimisation of the dilute PT for the detection of the lupus anticoagulant by use of a recombinant
tissue factor. Br. J. Haem. 87, 94-99, 1994.
13. Berrettini, M., Malaspina, M., Parise, P., Lucarelli, G., Kisiel, W.,
and Nenci, G.G. A simple chromogenic substrate assay of tissue factor pathway inhibitor in
plasma and serum. Am. J. Clin. Path. 103,391-395, 1995." name="eprints.referencetext" />
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<meta content="Tissue factor pathway inhibitor (TFPI) is a natural inhibitor that regulates the initiation of
coagulation by inhibiting tissue factor - activated factor VII (TF- FVIIa) in the presence of
activated factor X (FXa) (1). Although the precise role of TFPI in haemostasis is yet to be
determined, it's ability to inhibit TF - FVIla in the presence of FXa suggests that is does have an
important physiological significance.
TFPI levels have been reported to be normal in a variety of clinical conditions, including patients
with lupus anticoagulants (2,3). Lupus anticoagulants (LA) are acquired inhibitors, generally
considered to be immunoglobulins, that interfere with in vitro phospholipid dependent
coagulation tests (43). There is current interest in LA due to the associated thrombotic
complications as seen in increased risk for venous and arterial thrombosis as well as pregnancy
complications (6). We have previously reported decreased functional levels of TFPI in plasma
containing LA using a fluid phase assay, but normal levels with a binding assay (7). These low
levels of TFPI were shown to be corrected with the addition of excess TF (7).
As a continuation of this study, we again assessed TFPI levels in LA plasma using the same
fluid assay. The effect of using three different sources of tissue factor (recombinant, human
brain and rabbit brain thromboplastins) in the TFPI assay was examined. Of most significance
was the apparent correction of TFPI values as thromboplastin levels increased
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    <h1 class="ep_tm_pagetitle">Further investigations of lupus anticoagulant interference in a functional assay for tissue factor pathway inhibitor</h1>
    <p style="margin-bottom: 1em" class="not_ep_block"><span class="person_name">Adams, M.J.</span> and <span class="person_name">Oostryck, R.</span> (1997) <xhtml:em>Further investigations of lupus anticoagulant interference in a functional assay for tissue factor pathway inhibitor.</xhtml:em> Thrombosis Research, 87 (2). pp. 245-249. ISSN 0049-3848</p><p style="margin-bottom: 1em" class="not_ep_block"></p><table style="margin-bottom: 1em" class="not_ep_block"><tr><td valign="top" style="text-align:center"><a href="http://eprints.utas.edu.au/1814/1/Adams_et_al_1997.pdf"><img alt="[img]" src="http://eprints.utas.edu.au/style/images/fileicons/application_pdf.png" class="ep_doc_icon" border="0" /></a></td><td valign="top"><a href="http://eprints.utas.edu.au/1814/1/Adams_et_al_1997.pdf"><span class="ep_document_citation">PDF</span></a> - Full text restricted - Requires a PDF viewer<br />873Kb</td></tr></table><p style="margin-bottom: 1em" class="not_ep_block">Official URL: <a href="http://dx.doi.org/10.1016/S0049-3848(97)00124-2">http://dx.doi.org/10.1016/S0049-3848(97)00124-2</a></p><div class="not_ep_block"><h2>Abstract</h2><p style="padding-bottom: 16px; text-align: left; margin: 1em auto 0em auto">Tissue factor pathway inhibitor (TFPI) is a natural inhibitor that regulates the initiation of&#13;
coagulation by inhibiting tissue factor - activated factor VII (TF- FVIIa) in the presence of&#13;
activated factor X (FXa) (1). Although the precise role of TFPI in haemostasis is yet to be&#13;
determined, it's ability to inhibit TF - FVIla in the presence of FXa suggests that is does have an&#13;
important physiological significance.&#13;
TFPI levels have been reported to be normal in a variety of clinical conditions, including patients&#13;
with lupus anticoagulants (2,3). Lupus anticoagulants (LA) are acquired inhibitors, generally&#13;
considered to be immunoglobulins, that interfere with in vitro phospholipid dependent&#13;
coagulation tests (43). There is current interest in LA due to the associated thrombotic&#13;
complications as seen in increased risk for venous and arterial thrombosis as well as pregnancy&#13;
complications (6). We have previously reported decreased functional levels of TFPI in plasma&#13;
containing LA using a fluid phase assay, but normal levels with a binding assay (7). These low&#13;
levels of TFPI were shown to be corrected with the addition of excess TF (7).&#13;
As a continuation of this study, we again assessed TFPI levels in LA plasma using the same&#13;
fluid assay. The effect of using three different sources of tissue factor (recombinant, human&#13;
brain and rabbit brain thromboplastins) in the TFPI assay was examined. Of most significance&#13;
was the apparent correction of TFPI values as thromboplastin levels increased&#13;
</p></div><table style="margin-bottom: 1em" cellpadding="3" class="not_ep_block" border="0"><tr><th valign="top" class="ep_row">Item Type:</th><td valign="top" class="ep_row">Article</td></tr><tr><th valign="top" class="ep_row">Keywords:</th><td valign="top" class="ep_row">Tissue factor pathway inhibitor,tissue factor,lupus anticoagulan</td></tr><tr><th valign="top" class="ep_row">Subjects:</th><td valign="top" class="ep_row"><a href="http://eprints.utas.edu.au/view/subjects/321008.html">320000 Medical and Health Sciences &gt; 321000 Clinical Sciences &gt; 321008 Haematology</a></td></tr><tr><th valign="top" class="ep_row">ID Code:</th><td valign="top" class="ep_row">1814</td></tr><tr><th valign="top" class="ep_row">Deposited By:</th><td valign="top" class="ep_row"><span class="ep_name_citation"><span class="person_name">Dr Murray J Adams</span></span></td></tr><tr><th valign="top" class="ep_row">Deposited On:</th><td valign="top" class="ep_row">10 Sep 2007</td></tr><tr><th valign="top" class="ep_row">Last Modified:</th><td valign="top" class="ep_row">09 Jan 2008 02:30</td></tr><tr><th valign="top" class="ep_row">ePrint Statistics:</th><td valign="top" class="ep_row"><a target="ePrintStats" href="/es/index.php?action=show_detail_eprint;id=1814;">View statistics for this ePrint</a></td></tr></table><p align="right">Repository Staff Only: <a href="http://eprints.utas.edu.au/cgi/users/home?screen=EPrint::View&amp;eprintid=1814">item control page</a></p>
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