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  5.     <title>UTas ePrints - An electromyographic analysis of the effect of levodopa on the response time of healthy subjects</title>
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  13.     <meta content="Hasbroucq, T." name="eprints.creators_name" />
  14. <meta content="Tandonnet, Christophe" name="eprints.creators_name" />
  15. <meta content="Micallef-Roll, J." name="eprints.creators_name" />
  16. <meta content="Blin, O." name="eprints.creators_name" />
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  22. <meta content="2007-10-09 22:15:46" name="eprints.datestamp" />
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  25. <meta content="An electromyographic analysis of the effect of levodopa
  26. on the response time of healthy subjects" name="eprints.title" />
  27. <meta content="pub" name="eprints.ispublished" />
  28. <meta content="210000" name="eprints.subjects" />
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  31. <meta content="Levodopa · Healthy subjects · Reaction time ·
  32. Motor time" name="eprints.keywords" />
  33. <meta content="The original publication is available at www.springerlink.com
  34. " name="eprints.note" />
  35. <meta content="Abstract Rationale: Recently, we have shown that oral
  36. absorption of levodopa shortens reaction time (RT),
  37. measured as the interval between the response signal
  38. and the onset of voluntary electromyographic (EMG)
  39. activity. The motor time (MT) interval that elapses from
  40. the EMG activity to the mechanical response was not
  41. analysed. Objective: The purpose of the present study was
  42. to analyse the effect of the dose of levodopa administrated
  43. in our previous study on the MT. Eight healthy adults
  44. (aged 21–28, mean=25), performed a two-choice visual
  45. RT task after oral absorption of a single dose of levodopa
  46. (200 mg) or a placebo (randomized, double-blind, crossover
  47. design). Results: Like RT, MT was shorter under
  48. levodopa than under placebo. Statistical analyses demonstrated
  49. that this effect was present for all deciles of the RT
  50. and MT distributions. Conclusion: Levodopa shortens not
  51. only RT but also MT, which points at the implication of
  52. the dopaminergic system in both premotor and motor
  53. processes." name="eprints.abstract" />
  54. <meta content="2003" name="eprints.date" />
  55. <meta content="published" name="eprints.date_type" />
  56. <meta content="Psychopharmacology" name="eprints.publication" />
  57. <meta content="165" name="eprints.volume" />
  58. <meta content="313-316" name="eprints.pagerange" />
  59. <meta content="10.1007/s00213-002-1304-y" name="eprints.id_number" />
  60. <meta content="TRUE" name="eprints.refereed" />
  61. <meta content="0033-3158" name="eprints.issn" />
  62. <meta content="http://dx.doi.org/10.1007/s00213-002-1304-y" name="eprints.official_url" />
  63. <meta content="References
  64. Amalric M, Berhow M, Polis I, Koob GF (1993) Selective effects
  65. of low-dose dopamine receptor antagonism in a reaction-time
  66. task in rats. Neuropsychopharmacology 8:195–200
  67. Baunez C, Robbins TW (1999) Effects of dopamine depletion of
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  69. nucleus lesions in an attentional task in the rat. Neuroscience
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  82. working memory and planning in healthy young adults.
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  84. Fig. 1 Cumulative density functions for the three chronometric
  85. variables of the study. MT motor time, RT reaction time
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  100. exhaustive series. Behav Res Meth Instr 6:78
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  136. white rat. Behav Monogr 1:whole no. 5
  137. 316" name="eprints.referencetext" />
  138. <meta content="Hasbroucq, T. and Tandonnet, Christophe and Micallef-Roll, J. and Blin, O. (2003) An electromyographic analysis of the effect of levodopa on the response time of healthy subjects. Psychopharmacology, 165 . pp. 313-316. ISSN 0033-3158" name="eprints.citation" />
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  141. <meta content="An electromyographic analysis of the effect of levodopa
  142. on the response time of healthy subjects" name="DC.title" />
  143. <meta content="Hasbroucq, T." name="DC.creator" />
  144. <meta content="Tandonnet, Christophe" name="DC.creator" />
  145. <meta content="Micallef-Roll, J." name="DC.creator" />
  146. <meta content="Blin, O." name="DC.creator" />
  147. <meta content="210000 Science - General" name="DC.subject" />
  148. <meta content="440100 Philosophy" name="DC.subject" />
  149. <meta content="Abstract Rationale: Recently, we have shown that oral
  150. absorption of levodopa shortens reaction time (RT),
  151. measured as the interval between the response signal
  152. and the onset of voluntary electromyographic (EMG)
  153. activity. The motor time (MT) interval that elapses from
  154. the EMG activity to the mechanical response was not
  155. analysed. Objective: The purpose of the present study was
  156. to analyse the effect of the dose of levodopa administrated
  157. in our previous study on the MT. Eight healthy adults
  158. (aged 21–28, mean=25), performed a two-choice visual
  159. RT task after oral absorption of a single dose of levodopa
  160. (200 mg) or a placebo (randomized, double-blind, crossover
  161. design). Results: Like RT, MT was shorter under
  162. levodopa than under placebo. Statistical analyses demonstrated
  163. that this effect was present for all deciles of the RT
  164. and MT distributions. Conclusion: Levodopa shortens not
  165. only RT but also MT, which points at the implication of
  166. the dopaminergic system in both premotor and motor
  167. processes." name="DC.description" />
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  281.     <h1 class="ep_tm_pagetitle">An electromyographic analysis of the effect of levodopa on the response time of healthy subjects</h1>
  282.     <p style="margin-bottom: 1em" class="not_ep_block"><span class="person_name">Hasbroucq, T.</span> and <span class="person_name">Tandonnet, Christophe</span> and <span class="person_name">Micallef-Roll, J.</span> and <span class="person_name">Blin, O.</span> (2003) <xhtml:em>An electromyographic analysis of the effect of levodopa on the response time of healthy subjects.</xhtml:em> Psychopharmacology, 165 . pp. 313-316. ISSN 0033-3158</p><p style="margin-bottom: 1em" class="not_ep_block"></p><table style="margin-bottom: 1em" class="not_ep_block"><tr><td valign="top" style="text-align:center"><a href="http://eprints.utas.edu.au/2151/1/Hasbroucq%2CTandonnet%2CMicaleff-Roll%2CB.pdf"><img alt="[img]" src="http://eprints.utas.edu.au/style/images/fileicons/application_pdf.png" class="ep_doc_icon" border="0" /></a></td><td valign="top"><a href="http://eprints.utas.edu.au/2151/1/Hasbroucq%2CTandonnet%2CMicaleff-Roll%2CB.pdf"><span class="ep_document_citation">PDF</span></a> - Full text restricted - Requires a PDF viewer<br />142Kb</td><td><form method="get" accept-charset="utf-8" action="http://eprints.utas.edu.au/cgi/request_doc"><input accept-charset="utf-8" value="2694" name="docid" type="hidden" /><div class=""><input value="Request a copy" name="_action_null" class="ep_form_action_button" onclick="return EPJS_button_pushed( '_action_null' )" type="submit" /> </div></form></td></tr></table><p style="margin-bottom: 1em" class="not_ep_block">Official URL: <a href="http://dx.doi.org/10.1007/s00213-002-1304-y">http://dx.doi.org/10.1007/s00213-002-1304-y</a></p><div class="not_ep_block"><h2>Abstract</h2><p style="padding-bottom: 16px; text-align: left; margin: 1em auto 0em auto">Abstract Rationale: Recently, we have shown that oral&#13;
  283. absorption of levodopa shortens reaction time (RT),&#13;
  284. measured as the interval between the response signal&#13;
  285. and the onset of voluntary electromyographic (EMG)&#13;
  286. activity. The motor time (MT) interval that elapses from&#13;
  287. the EMG activity to the mechanical response was not&#13;
  288. analysed. Objective: The purpose of the present study was&#13;
  289. to analyse the effect of the dose of levodopa administrated&#13;
  290. in our previous study on the MT. Eight healthy adults&#13;
  291. (aged 21–28, mean=25), performed a two-choice visual&#13;
  292. RT task after oral absorption of a single dose of levodopa&#13;
  293. (200 mg) or a placebo (randomized, double-blind, crossover&#13;
  294. design). Results: Like RT, MT was shorter under&#13;
  295. levodopa than under placebo. Statistical analyses demonstrated&#13;
  296. that this effect was present for all deciles of the RT&#13;
  297. and MT distributions. Conclusion: Levodopa shortens not&#13;
  298. only RT but also MT, which points at the implication of&#13;
  299. the dopaminergic system in both premotor and motor&#13;
  300. processes.</p></div><table style="margin-bottom: 1em" cellpadding="3" class="not_ep_block" border="0"><tr><th valign="top" class="ep_row">Item Type:</th><td valign="top" class="ep_row">Article</td></tr><tr><th valign="top" class="ep_row">Additional Information:</th><td valign="top" class="ep_row">The original publication is available at www.springerlink.com&#13;
  301. </td></tr><tr><th valign="top" class="ep_row">Keywords:</th><td valign="top" class="ep_row">Levodopa · Healthy subjects · Reaction time ·&#13;
  302. Motor time</td></tr><tr><th valign="top" class="ep_row">Subjects:</th><td valign="top" class="ep_row"><a href="http://eprints.utas.edu.au/view/subjects/210000.html">210000 Science - General</a><br /><a href="http://eprints.utas.edu.au/view/subjects/440100.html">440000 Philosophy and Religion &gt; 440100 Philosophy</a></td></tr><tr><th valign="top" class="ep_row">ID Code:</th><td valign="top" class="ep_row">2151</td></tr><tr><th valign="top" class="ep_row">Deposited By:</th><td valign="top" class="ep_row"><span class="ep_name_citation"><span class="person_name">Scholarly Publications Librarian</span></span></td></tr><tr><th valign="top" class="ep_row">Deposited On:</th><td valign="top" class="ep_row">10 Oct 2007 09:15</td></tr><tr><th valign="top" class="ep_row">Last Modified:</th><td valign="top" class="ep_row">09 Jan 2008 02:30</td></tr><tr><th valign="top" class="ep_row">ePrint Statistics:</th><td valign="top" class="ep_row"><a target="ePrintStats" href="/es/index.php?action=show_detail_eprint;id=2151;">View statistics for this ePrint</a></td></tr></table><p align="right">Repository Staff Only: <a href="http://eprints.utas.edu.au/cgi/users/home?screen=EPrint::View&amp;eprintid=2151">item control page</a></p>
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