<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN"
"http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
<html>
<head>
<title>UTas ePrints - Detection and mapping of QTL on bovine chromosomes 2 and 5 segregating for live weight, average daily gain and body measurements in Japanese Black Cattle</title>
<script type="text/javascript" src="http://eprints.utas.edu.au/javascript/auto.js"><!-- padder --></script>
<style type="text/css" media="screen">@import url(http://eprints.utas.edu.au/style/auto.css);</style>
<style type="text/css" media="print">@import url(http://eprints.utas.edu.au/style/print.css);</style>
<link rel="icon" href="/images/eprints/favicon.ico" type="image/x-icon" />
<link rel="shortcut icon" href="/images/eprints/favicon.ico" type="image/x-icon" />
<link rel="Top" href="http://eprints.utas.edu.au/" />
<link rel="Search" href="http://eprints.utas.edu.au/cgi/search" />
<meta content="Malau-Aduli, A.E.O." name="eprints.creators_name" />
<meta content="Niibayashi, T." name="eprints.creators_name" />
<meta content="Kojima, T." name="eprints.creators_name" />
<meta content="Oshima, K." name="eprints.creators_name" />
<meta content="Mizoguchi, Y." name="eprints.creators_name" />
<meta content="Komatsu, M." name="eprints.creators_name" />
<meta content="Aduli.MalauAduli@utas.edu.au" name="eprints.creators_id" />
<meta name="eprints.creators_id" />
<meta name="eprints.creators_id" />
<meta name="eprints.creators_id" />
<meta name="eprints.creators_id" />
<meta name="eprints.creators_id" />
<meta content="article" name="eprints.type" />
<meta content="2008-01-23 02:45:49" name="eprints.datestamp" />
<meta content="2008-01-24T00:02:12Z" name="eprints.lastmod" />
<meta content="show" name="eprints.metadata_visibility" />
<meta content="Detection and mapping of QTL on bovine
chromosomes 2 and 5 segregating for live weight,
average daily gain and body measurements in
Japanese Black Cattle" name="eprints.title" />
<meta content="pub" name="eprints.ispublished" />
<meta content="270200" name="eprints.subjects" />
<meta content="270207" name="eprints.subjects" />
<meta content="300401" name="eprints.subjects" />
<meta content="270208" name="eprints.subjects" />
<meta content="300406" name="eprints.subjects" />
<meta content="300400" name="eprints.subjects" />
<meta content="270800" name="eprints.subjects" />
<meta content="public" name="eprints.full_text_status" />
<meta content="QTL mapping, Japanese Black cattle, BTA2, BTA5, body measurements, live weight, daily gain." name="eprints.keywords" />
<meta content="Bovine chromosomes 2 (BTA2) and 5 (BTA5) of purebred, half-sib progeny sired by five Japanese black
bulls were genotyped using microsatellite DNA markers. The data were subjected to linkage analysis for
the detection and mapping of segregating quantitative trait loci (QTL) influencing live weight, average
daily gain and body measurements at weaning. Probability coefficients of inheriting allele 1 or 2 from the
sire at specific chromosomal intervals were computed. The phenotypic data on progeny were regressed on
these probability coefficients in a within-common-parent regression analysis. Fixed effects of sex, parity
and season of birth as well as age as a covariate, were fitted in a linear model to the phenotypic data and
subsequently analysed using QTL Express by generating an F-statistic through permutation tests at
chromosome-wide significance thresholds over 10, 000 iterations at 1 cM intervals. Highly significant
(P<0.01) segregating QTL for body measurements were detected on BTA2 for hip width (1 cM) and chest
depth (8 cM) in Sire Family 1 and pin bone width (16 cM) in Sire Family 3. Other significant QTL (P<0.05)
detected were withers height (3 cM), hip height (4 cM), body length (4 cM), shoulder width (6 cM), lumbar
width (3 cM), thurl width (3 cM) and canon circumference (2 cM) in Sire Family 1, shoulder width (16 cM) in
Sire Family 3 and thurl width (24 cM), pin bone width (19 cM), heart girth (26 cM) and abdominal width (69
cM) in Sire Family 4. Significant (P<0.05) QTL for live weight and average daily gain were detected on BTA2
for birth weight (5 cM) and weaning weight (3 cM) in Sire Family 1 and post-weaning average daily gain (68
cM) in Sire Family 4. BTA 5 contained QTL for birth weight, pin bone width and heart girth in Sire Family 3
that were only suggestive and not significant. Such localization of economically important QTL as
demonstrated in this study, will expedite genetic improvement via marker-assisted selection, gene
introgression and positional cloning in Japanese black cattle." name="eprints.abstract" />
<meta content="2007" name="eprints.date" />
<meta content="published" name="eprints.date_type" />
<meta content="Journal of Cell and Animal Biology" name="eprints.publication" />
<meta content="1" name="eprints.volume" />
<meta content="3" name="eprints.number" />
<meta content="034-043" name="eprints.pagerange" />
<meta content="TRUE" name="eprints.refereed" />
<meta content="1996-0867" name="eprints.issn" />
<meta content="http://www.academicjournals.org/JCAB/contents/2007cont/Oct.htm" name="eprints.official_url" />
<meta content="Allan MF, Thallman RM, Cushman RA, Echternkamp SE, White SN,
Kuehn LA, Casas E, Smith TPL (2007). Association of a single
nucleotide polymorphism in SPP1 with growth traits and twinning in a
cattle population selected for twinning rate. J. Anim. Sci. 85:341-347.
Casas E, Keele JW, Shackleford SD, Stone RT, Koohmaraie M,
Sonstegard TS, Smith TPL (1998). Association of the muscle
hypertrophy locus with carcass traits in beef cattle. J. Anim. Sci. 76:
468-473.
Casas E, Shackleford SD, Keele JW, Koohmaraie M, Smith TPL, Stone
RT (2003). Detection of quantitative trait loci for growth and carcass
composition in cattle. J. Anim. Sci. 81: 2976-2983.
Casas E, Shackleford SD, Keele JW, Stone RT, Kappes SM,
Koohmaraie M (2000). Quantitative trait loci affecting growth and
carcass composition of cattle segregating alternate forms of myostatin.
J. Anim. Sci. 78: 560-569.
Casas E, Stone RT (2006). Putative quantitative trait loci associated
with the probability of contracting infectious bovine keratoconjunctivitis.
J. Anim. Sci. 84: 3180-3184.
Casas E, White SN, Riley DG, Smith TPL, Brenneman RA, Olson TA,
Johnson DD, Coleman SW, Bennett GL, Chase Jr CC (2005).
Assessment of single nucleotide polymorphisms in genes residing on
chromosomes 14 and 29 for association with carcass composition
traits in Bos indicus cattle. J. Anim. Sci. 83: 13-19.
Casas E, White SN, Shackelford SD, Wheeler TL, Koohmaraie M,
Bennett GL, Smith TPL (2007). Assessing association of single
nucleotide polymorphisms at the thyroglobulin gene with carcass
traits in beef cattle. J. Anim. Sci. 85: 0179v1
Churchill GA, Doerge RW (1994). Empirical threshold values for quantitative
trait mapping. Genet. 138: 963-971.
Davis GP, Hetzel DJS, Corbet NJ, Scacheri S, Lowden S, Renaud J,
Mayne C, Stevenson R, Moore SS, Byrne K (1998).The mapping of
quantitative trait loci for birth weight in a tropical beef herd. Proc. 6th
Wld. Congr. Genet. Appl. Livest. Prod. 26: 441-444.
De Koning DJ, Schulmant NF, Elo K, Moisio S, Kinos R, Vilkki J, Maki-
Tanila A (2001). Mapping of multiple quantitative trait loci by simple
regression in half-sib designs. J. Anim. Sci. 79: 616-622.
De Koning DJ, Visscher PM, Knott SA, Haley CS (1998). A strategy for
QTL detection in half-sib populations. Anim. Sci. 67: 257-268.
Dekkers JCM (2004). Commercial application of marker- and geneassisted
selection in livestock: Strategies and lessons. J. Anim. Sci.
82 (E. Suppl.): E313–E328.
Doerge RW, Churchill GA (1996). Permutation tests for multiple loci
affecting a quantitative character. Genet. 142: 285-294.
Georges M, Dietz AB, Mishra A, Nielsen D, Sargent LS, Sorensen A,
Steele MR, Zhao X, Leipold H, Womack JE, Lathrop M (1993).
Microsatellite mapping of the gene causing weaver disease in cattle
will allow the study an associated quantitative trait locus. Proc. Natl.
Acad. Sci. U.S.A. 90: 1058-1062.
Grosz MD, MacNeil MD (2001). Putative quantitative trait locus affecting
birth weight on bovine chromosome 2. J. Anim. Sci. 79: 68-72.
Haley CS, Knott SA (1992). A simple regression method for mapping
quantitative trait loci in line crosses using flanking markers. Genetics
132: 1211-1222.
Kappes SM, Keele JW, Stone RT, McGraw RA, Sonstegard TS, Smith
TPL, Lopez-Corrales NL, Beattie CW (1997). A second generation
linkage map of the bovine genome. Genome Res. 7: 235-249.
Kim JJ, Farnir F, Taylor JF (2003). Detection of quantitative trait loci for
growth and beef carcass fatness traits in a cross between Bos taurus
(Angus) and Bos indicus (Brahman) cattle. J. Anim. Sci. 81: 1933-
1942.
Kitamura C, Yasuda Y, Kobayashi T, Nomura T, Shimada K (1999).
Genetic analysis of direct and maternal effects for calf market and
carcass weights in Japanese Black cattle. Asian-Aust. J. Anim. Sci.
12: 843-845.
Kneeland J, Li C, Basarab J, Snelling WM, Benkel B, Murdoch B,
Hansen C, Moore SS (2004). Identification and fine mapping of
quantitative trait loci for growth traits on bovine chromosomes 2, 6, 14,
19, 21 and 23 within one commercial line of Bos taurus. J. Anim. Sci.
82: 3405-3414.
Knott SA, Elsen JM, Haley CS (1996). Methods for multiple markers
mapping of quantitative trait loci in half-sib populations. Theoret. Appl.
Genet. 93: 71-80.
Li C, Basarab J, Snelling WM, Benkel B, Kneeland J, Murdoch B, Hansen
C, Moore SS (2004a). Identification and fine mapping of quantitative
trait loci for backfat on bovine chromosomes 2, 5, 6, 19, 21 and
23 in a commercial line of Bos taurus. J. Anim. Sci. 82: 967-972.
Li C, Basarab J, Snelling WM, Benkel B, Murdoch B, Hansen C, Moore
SS (2004b). Assessment of positional candidate genes myf5 and igf1
for growth on bovine chromosome 5 in commercial lines of Bos
taurus. J. Anim. Sci. 82: 1-7.
Li C, Basarab J, Snelling WM, Benke B, Murdoch B, Moore SS (2002).
The identification of common haplotypes on bovine chromosome 5
within commercial lines of Bos taurus and their associations with
growth traits. J. Anim. Sci. 80: 1187-1194.
Lusk JL (2007). Association of single nucleotide polymorphisms in the
leptin gene with body weight and backfat growth curve parameters for
beef cattle. J. Anim Sci. 85:1865-1872.
Macneil MD, Grosz MD (2002). Genome-wide scans for QTL affecting
carcass traits in Hereford x composite double backcross populations.
J. Anim. Sci. 80: 2316-2324.
Malau-Aduli AEO, Aziz MA, Kojima T, Niibayashi T, Oshima K, Komatsu
M (2004a). Fixing collinearity instability using principal component
and ridge regression analyses in the relationship between body
measurements and body weight in Japanese Black cattle. J. Anim.
Vet. Adv. 3: 856-863.
Malau-Aduli AEO, Niibayashi T, Kojima T, Oshima K, Komatsu M
(2003a). Genome-wide scanning for QTL: Mapping methodology and
detected QTL in cattle. J. Anim. Genet. 30:3-16.
Malau-Aduli AEO, Niibayashi T, Kojima T, Oshima K, Mizoguchi Y,
Komatsu M (2005a). Mapping the quantitative trait loci (QTL) for body
shape and conformation measurements on BTA1 in Japanese Black cattle. Anim. Sci. J. 76: 19-27.
Malau-Aduli AEO, Niibayashi T, Kojima T, Oshima K, Mizoguchi Y,
Komatsu M (2005b). Interval mapping of growth quantitative trait loci
in Japanese Black beef cattle using microsatellite DNA markers and
half-sib regression analysis. Anim. Sci. J. 76: 11-18.
Malau-Aduli AEO, Niibayashi T, Kojima T, Oshima K, Mizoguchi Y,
Sugimoto Y, Komatsu M (2003b). Microsatellite DNA marker mapping
of bovine chromosome one for QTL affecting birth weight and
preweaning growth in Japanese Black cattle (Wagyu). In: Linda
Hygate (Editor). 50 years of DNA. Proc. Assoc. Advance. Anim.
Breed. Genet. 15: 14-17.
Malau-Aduli AEO, Nishimura-Abe A, Niibayashi T, Yasuda Y, Kojima T,
Abe S, Oshima K, Hasegawa K, Komatsu M (2004b). Mitochondrial
DNA polymorphism, maternal lineage and correlations with postnatal
growth of Japanese Black beef cattle to yearling age. Asian-Aust. J.
Anim. Sci. 17: 1484-1490.
Mizoshita K, Watanabe T, Hayashi H, Kubota C, Yamakuchi H,
Todoroki J, Sugimoto Y (2004). Quantitative trait loci analysis for
growth and carcass traits in a half-sib family of purebred Japanese
Black (Wagyu) cattle. J. Anim. Sci. 82: 3415-3420.
Mukai F, Oyama K, Kohno S (1995). Genetic relationships between
performance test traits and field carcass traits in Japanese Black
cattle. Livest. Prod. Sci. 44: 199-205.
Mukai F, Sadahira M, Yoshimura T (2004). Comparison of carcass
composition among Japanese Black, Holstein and their crossbred
steers fattening on-farm. Anim. Sci. J. 75: 393-399.
Mukai F, Yamagami A, Anada K (2000). Estimation of genetic parameters
and trends for additive, direct maternal genetic effects for birth
and calf market weights in Japanese Black beef cattle. Anim. Sci. J.
71: 462-469.
Napolitano F, Catillo G, Lucioli S, Carretta A, Di Giacomo A, Rossi G,
Moioli BM (2001). Evidence for quantitative trait locus for conformation
traits on chromosome 19 in beef cattle. J. Anim. Breed. Genet.
118: 119-124.
Napolitano F , Leone P, Puppo S, Moioli BM, Pilla F, Comincini S,
Ferretti L, Carretta A (1996). Exploitation of microsatellites as genetic
markers of beef performance traits in Piemontese x Chianina crossbred
cattle. J. Anim. Breed. Genet. 113: 157-162.
Nkrumah JD, Li C, Yu J, Hansen C, Keisler DH, Moore SS (2005).
Polymorphisms in the bovine leptin promoter associated with serum
leptin concentration, growth, feed intake, feeding behaviour, and
measures of carcass merit. J. Anim. Sci. 83: 20-28.
Oyama K, Mukai F, Yoshimura T (1996). Genetic relationships among
traits recorded at registry judgement, reproductive traits of breeding
females and carcass traits of fattening animals in Japanese Black
cattle. Anim. Sci. Technol. (Japan) 67: 511-518.
Rincker CB, Pyatt NA, Berger LL, Faulkner DB (2006). Relationship
among GeneSTAR marbling marker, intramuscular fat deposition,
and expected progeny differences in early weaned Simmental steers.
J. Anim. Sci. 84: 686-693.
Sambrook J, Fritsch EF, Maniatis T (1989). Molecular cloning. A
laboratory manual, 2nd Edition, Cold Spring Harbor Laboratory Press,
New York, USA.
SAS (2002). Statistical Analysis System. SAS Institute Inc., Cary, North
Carolina, USA.
Sasaki K, Mitsumoto M (2004). Questionnaire-based study on consumer
requirements for beef quality in Japan. Anim. Sci. J. 75: 369-376.
Schenkel FS, Miller SP, Ye X, Moore SS, Nkrumah JD, Li C, Yu J,
Mandell IB, Wilton JW, Williams JL (2005). Association of single
nucleotide polymorphisms in the leptin gene with carcass and meat
quality traits of beef cattle. J. Anim Sci 83: 2009-2020.
Seaton G, Haley CS, Knott SA, Kearsey M, Visscher PM (2002). QTL
express: mapping quantitative trait loci in simple and complex pedigrees.
Bioinformatics 18: 339-340.
Spelman RJ, Coppieters WL, Karim A, van Arendok JAM, Bovenhuis H
(1996). Quantitative trait loci analysis for five milk production traits on
chromosome six in the Dutch Holstein-Friesian population. Genet.
144: 1799-1808.
Stone RT, Casas E, Smith TPL, Keele JW, Harhay G, Bennett GL,
Koohmaraie M, Wheeler TL, Shackelford SD, Snelling WM (2005).
Identification of genetic markers for fat deposition and meat tenderness
on bovine chromosome 5: Development of a low-density single nucleotide polymorphism map. J. Anim. Sci. 83: 2280-2288.
Stone RT, Keele JW, Shackleford SD, Kappes SM, Koohmaraie M
(1999). A primary screen of the bovine genome for quantitative trait
loci affecting carcass and growth traits. J. Anim. Sci. 77: 1379-1384.
Tambasco DD, Paz CC, Tambasco-Studart M, Pereira AP, Alencar MM,
Freitas AR, Coutinho LL, Packer IU, Regitano LCA (2003). Candidate
genes for growth traits in beef cattle crosses Bos taurus x Bos indicus.
J. Anim. Breed. Genet. 120: 51-56.
Van Eenennaam AL, Li J, Thallman RM, Quaas RL, Dikeman ME, Gill
CA, Franke DE, Thomas MG (2007). Validation of commercial DNA
tests for quantitative beef quality traits. J. Anim. Sci. 85:891-900.
Vilkki HJ, de Koning DJ, Elo KT, Velmala RJ, Maki-Tanila AV (1997).
Multiple marker mapping of quantitative trait loci of Finnish dairy
cattle by regression. J. Dairy Sci. 73: 2525-2537.
White SN, Casas E, Allan MF, Keele JW, Snelling WM, Wheeler TL,
Shackelford SD, M. Koohmaraie M, Smith TPL (2007). Beef cattle
evaluation of six DNA markers developed for dairy traits reveals an
osteopontin polymorphism is associated with postweaning growth. J.
Anim. Sci. 85:1–10.
White SN, Casas E, Wheeler TL, Shackelford SD, Koohmaraie M, Riley
DG, Chase Jr. CC, Johnson DD, Keele JW, Smith TPL (2005). A
new single nucleotide polymorphism in CAPN1 extends the current
tenderness marker test to include cattle of Bos indicus, Bos taurus
and crossbred descent. J. Anim. Sci. 83: 2001-2008." name="eprints.referencetext" />
<meta content="Malau-Aduli, A.E.O. and Niibayashi, T. and Kojima, T. and Oshima, K. and Mizoguchi, Y. and Komatsu, M. (2007) Detection and mapping of QTL on bovine chromosomes 2 and 5 segregating for live weight, average daily gain and body measurements in Japanese Black Cattle. Journal of Cell and Animal Biology, 1 (3). pp. 034-043. ISSN 1996-0867" name="eprints.citation" />
<meta content="http://eprints.utas.edu.au/3083/2/Malau-Adulietal2007JCAB.pdf" name="eprints.document_url" />
<link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" />
<meta content="Detection and mapping of QTL on bovine
chromosomes 2 and 5 segregating for live weight,
average daily gain and body measurements in
Japanese Black Cattle" name="DC.title" />
<meta content="Malau-Aduli, A.E.O." name="DC.creator" />
<meta content="Niibayashi, T." name="DC.creator" />
<meta content="Kojima, T." name="DC.creator" />
<meta content="Oshima, K." name="DC.creator" />
<meta content="Mizoguchi, Y." name="DC.creator" />
<meta content="Komatsu, M." name="DC.creator" />
<meta content="270200 Genetics" name="DC.subject" />
<meta content="270207 Quantitative Genetics" name="DC.subject" />
<meta content="300401 Animal Breeding" name="DC.subject" />
<meta content="270208 Molecular Evolution" name="DC.subject" />
<meta content="300406 Animal Growth and Development" name="DC.subject" />
<meta content="300400 Animal Production" name="DC.subject" />
<meta content="270800 Biotechnology" name="DC.subject" />
<meta content="Bovine chromosomes 2 (BTA2) and 5 (BTA5) of purebred, half-sib progeny sired by five Japanese black
bulls were genotyped using microsatellite DNA markers. The data were subjected to linkage analysis for
the detection and mapping of segregating quantitative trait loci (QTL) influencing live weight, average
daily gain and body measurements at weaning. Probability coefficients of inheriting allele 1 or 2 from the
sire at specific chromosomal intervals were computed. The phenotypic data on progeny were regressed on
these probability coefficients in a within-common-parent regression analysis. Fixed effects of sex, parity
and season of birth as well as age as a covariate, were fitted in a linear model to the phenotypic data and
subsequently analysed using QTL Express by generating an F-statistic through permutation tests at
chromosome-wide significance thresholds over 10, 000 iterations at 1 cM intervals. Highly significant
(P<0.01) segregating QTL for body measurements were detected on BTA2 for hip width (1 cM) and chest
depth (8 cM) in Sire Family 1 and pin bone width (16 cM) in Sire Family 3. Other significant QTL (P<0.05)
detected were withers height (3 cM), hip height (4 cM), body length (4 cM), shoulder width (6 cM), lumbar
width (3 cM), thurl width (3 cM) and canon circumference (2 cM) in Sire Family 1, shoulder width (16 cM) in
Sire Family 3 and thurl width (24 cM), pin bone width (19 cM), heart girth (26 cM) and abdominal width (69
cM) in Sire Family 4. Significant (P<0.05) QTL for live weight and average daily gain were detected on BTA2
for birth weight (5 cM) and weaning weight (3 cM) in Sire Family 1 and post-weaning average daily gain (68
cM) in Sire Family 4. BTA 5 contained QTL for birth weight, pin bone width and heart girth in Sire Family 3
that were only suggestive and not significant. Such localization of economically important QTL as
demonstrated in this study, will expedite genetic improvement via marker-assisted selection, gene
introgression and positional cloning in Japanese black cattle." name="DC.description" />
<meta content="2007" name="DC.date" />
<meta content="Article" name="DC.type" />
<meta content="PeerReviewed" name="DC.type" />
<meta content="application/pdf" name="DC.format" />
<meta content="http://eprints.utas.edu.au/3083/2/Malau-Adulietal2007JCAB.pdf" name="DC.identifier" />
<meta content="http://www.academicjournals.org/JCAB/contents/2007cont/Oct.htm" name="DC.relation" />
<meta content="Malau-Aduli, A.E.O. and Niibayashi, T. and Kojima, T. and Oshima, K. and Mizoguchi, Y. and Komatsu, M. (2007) Detection and mapping of QTL on bovine chromosomes 2 and 5 segregating for live weight, average daily gain and body measurements in Japanese Black Cattle. Journal of Cell and Animal Biology, 1 (3). pp. 034-043. ISSN 1996-0867" name="DC.identifier" />
<meta content="http://eprints.utas.edu.au/3083/" name="DC.relation" />
<link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/3083/BibTeX/epprod-eprint-3083.bib" title="BibTeX" type="text/plain" />
<link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/3083/ContextObject/epprod-eprint-3083.xml" title="OpenURL ContextObject" type="text/xml" />
<link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/3083/ContextObject::Dissertation/epprod-eprint-3083.xml" title="OpenURL Dissertation" type="text/xml" />
<link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/3083/ContextObject::Journal/epprod-eprint-3083.xml" title="OpenURL Journal" type="text/xml" />
<link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/3083/DC/epprod-eprint-3083.txt" title="Dublin Core" type="text/plain" />
<link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/3083/DIDL/epprod-eprint-3083.xml" title="DIDL" type="text/xml" />
<link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/3083/EndNote/epprod-eprint-3083.enw" title="EndNote" type="text/plain" />
<link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/3083/HTML/epprod-eprint-3083.html" title="HTML Citation" type="text/html; charset=utf-8" />
<link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/3083/METS/epprod-eprint-3083.xml" title="METS" type="text/xml" />
<link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/3083/MODS/epprod-eprint-3083.xml" title="MODS" type="text/xml" />
<link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/3083/RIS/epprod-eprint-3083.ris" title="Reference Manager" type="text/plain" />
<link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/3083/Refer/epprod-eprint-3083.refer" title="Refer" type="text/plain" />
<link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/3083/Simple/epprod-eprint-3083text" title="Simple Metadata" type="text/plain" />
<link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/3083/Text/epprod-eprint-3083.txt" title="ASCII Citation" type="text/plain; charset=utf-8" />
<link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/3083/XML/epprod-eprint-3083.xml" title="EP3 XML" type="text/xml" />
</head>
<body bgcolor="#ffffff" text="#000000" onLoad="loadRoutine(); MM_preloadImages('images/eprints/ePrints_banner_r5_c5_f2.gif','images/eprints/ePrints_banner_r5_c7_f2.gif','images/eprints/ePrints_banner_r5_c8_f2.gif','images/eprints/ePrints_banner_r5_c9_f2.gif','images/eprints/ePrints_banner_r5_c10_f2.gif','images/eprints/ePrints_banner_r5_c11_f2.gif','images/eprints/ePrints_banner_r6_c4_f2.gif')">
<div class="ep_noprint"><noscript><style type="text/css">@import url(http://eprints.utas.edu.au/style/nojs.css);</style></noscript></div>
<table width="795" border="0" cellspacing="0" cellpadding="0">
<tr>
<td><script language="JavaScript1.2">mmLoadMenus();</script>
<table border="0" cellpadding="0" cellspacing="0" width="795">
<!-- fwtable fwsrc="eprints_banner_final2.png" fwbase="ePrints_banner.gif" fwstyle="Dreamweaver" fwdocid = "1249563342" fwnested="0" -->
<tr>
<td><img src="/images/eprints/spacer.gif" width="32" height="1" border="0" alt="" /></td>
<td><img src="/images/eprints/spacer.gif" width="104" height="1" border="0" alt="" /></td>
<td><img src="/images/eprints/spacer.gif" width="44" height="1" border="0" alt="" /></td>
<td><img src="/images/eprints/spacer.gif" width="105" height="1" border="0" alt="" /></td>
<td><img src="/images/eprints/spacer.gif" width="41" height="1" border="0" alt="" /></td>
<td><img src="/images/eprints/spacer.gif" width="16" height="1" border="0" alt="" /></td>
<td><img src="/images/eprints/spacer.gif" width="68" height="1" border="0" alt="" /></td>
<td><img src="/images/eprints/spacer.gif" width="68" height="1" border="0" alt="" /></td>
<td><img src="/images/eprints/spacer.gif" width="68" height="1" border="0" alt="" /></td>
<td><img src="/images/eprints/spacer.gif" width="82" height="1" border="0" alt="" /></td>
<td><img src="/images/eprints/spacer.gif" width="69" height="1" border="0" alt="" /></td>
<td><img src="/images/eprints/spacer.gif" width="98" height="1" border="0" alt="" /></td>
<td><img src="/images/eprints/spacer.gif" width="1" height="1" border="0" alt="" /></td>
</tr>
<tr>
<td colspan="12"><img name="ePrints_banner_r1_c1" src="/images/eprints/ePrints_banner_r1_c1.gif" width="795" height="10" border="0" alt="" /></td>
<td><img src="/images/eprints/spacer.gif" width="1" height="10" border="0" alt="" /></td>
</tr>
<tr>
<td rowspan="6"><img name="ePrints_banner_r2_c1" src="/images/eprints/ePrints_banner_r2_c1.gif" width="32" height="118" border="0" alt="" /></td>
<td rowspan="5"><a href="http://www.utas.edu.au/"><img name="ePrints_banner_r2_c2" src="/images/eprints/ePrints_banner_r2_c2.gif" width="104" height="103" border="0" alt="" /></a></td>
<td colspan="10"><img name="ePrints_banner_r2_c3" src="/images/eprints/ePrints_banner_r2_c3.gif" width="659" height="41" border="0" alt="" /></td>
<td><img src="/images/eprints/spacer.gif" width="1" height="41" border="0" alt="" /></td>
</tr>
<tr>
<td colspan="3"><a href="http://eprints.utas.edu.au/"><img name="ePrints_banner_r3_c3" src="/images/eprints/ePrints_banner_r3_c3.gif" width="190" height="31" border="0" alt="" /></a></td>
<td rowspan="2" colspan="7"><img name="ePrints_banner_r3_c6" src="/images/eprints/ePrints_banner_r3_c6.gif" width="469" height="37" border="0" alt="" /></td>
<td><img src="/images/eprints/spacer.gif" width="1" height="31" border="0" alt="" /></td>
</tr>
<tr>
<td colspan="3"><img name="ePrints_banner_r4_c3" src="/images/eprints/ePrints_banner_r4_c3.gif" width="190" height="6" border="0" alt="" /></td>
<td><img src="/images/eprints/spacer.gif" width="1" height="6" border="0" alt="" /></td>
</tr>
<tr>
<td colspan="2"><img name="ePrints_banner_r5_c3" src="/images/eprints/ePrints_banner_r5_c3.gif" width="149" height="1" border="0" alt="" /></td>
<td rowspan="2" colspan="2"><a href="/information.html" onMouseOut="MM_swapImgRestore();MM_startTimeout()" onMouseOver="MM_showMenu(window.mm_menu_0821132634_0,0,25,null,'ePrints_banner_r5_c5');MM_swapImage('ePrints_banner_r5_c5','','/images/eprints/ePrints_banner_r5_c5_f2.gif',1);"><img name="ePrints_banner_r5_c5" src="/images/eprints/ePrints_banner_r5_c5.gif" width="57" height="25" border="0" alt="About" /></a></td>
<td rowspan="2"><a href="/view/" onMouseOut="MM_swapImgRestore();MM_startTimeout()" onMouseOver="MM_showMenu(window.mm_menu_0821133021_1,0,25,null,'ePrints_banner_r5_c7');MM_swapImage('ePrints_banner_r5_c7','','/images/eprints/ePrints_banner_r5_c7_f2.gif',1);"><img name="ePrints_banner_r5_c7" src="/images/eprints/ePrints_banner_r5_c7.gif" width="68" height="25" border="0" alt="Browse" /></a></td>
<td rowspan="2"><a href="/perl/search/simple" onMouseOut="MM_swapImgRestore();MM_startTimeout()" onMouseOver="MM_showMenu(window.mm_menu_0821133201_2,0,25,null,'ePrints_banner_r5_c8');MM_swapImage('ePrints_banner_r5_c8','','/images/eprints/ePrints_banner_r5_c8_f2.gif',1);"><img name="ePrints_banner_r5_c8" src="/images/eprints/ePrints_banner_r5_c8.gif" width="68" height="25" border="0" alt="Search" /></a></td>
<td rowspan="2"><a href="/perl/register" onMouseOut="MM_swapImgRestore();MM_startTimeout();" onMouseOver="MM_showMenu(window.mm_menu_1018171924_3,0,25,null,'ePrints_banner_r5_c9');MM_swapImage('ePrints_banner_r5_c9','','/images/eprints/ePrints_banner_r5_c9_f2.gif',1);"><img name="ePrints_banner_r5_c9" src="/images/eprints/ePrints_banner_r5_c9.gif" width="68" height="25" border="0" alt="register" /></a></td>
<td rowspan="2"><a href="/perl/users/home" onMouseOut="MM_swapImgRestore();MM_startTimeout()" onMouseOver="MM_showMenu(window.mm_menu_0821133422_4,0,25,null,'ePrints_banner_r5_c10');MM_swapImage('ePrints_banner_r5_c10','','/images/eprints/ePrints_banner_r5_c10_f2.gif',1);"><img name="ePrints_banner_r5_c10" src="/images/eprints/ePrints_banner_r5_c10.gif" width="82" height="25" border="0" alt="user area" /></a></td>
<td rowspan="2"><a href="/help/" onMouseOut="MM_swapImgRestore();MM_startTimeout()" onMouseOver="MM_showMenu(window.mm_menu_0821133514_5,0,25,null,'ePrints_banner_r5_c11');MM_swapImage('ePrints_banner_r5_c11','','/images/eprints/ePrints_banner_r5_c11_f2.gif',1);"><img name="ePrints_banner_r5_c11" src="/images/eprints/ePrints_banner_r5_c11.gif" width="69" height="25" border="0" alt="Help" /></a></td>
<td rowspan="3" colspan="4"><img name="ePrints_banner_r5_c12" src="/images/eprints/ePrints_banner_r5_c12.gif" width="98" height="40" border="0" alt="" /></td>
<td><img src="/images/eprints/spacer.gif" width="1" height="1" border="0" alt="" /></td>
</tr>
<tr>
<td rowspan="2"><img name="ePrints_banner_r6_c3" src="/images/eprints/ePrints_banner_r6_c3.gif" width="44" height="39" border="0" alt="ePrints home" /></td>
<td><a href="/" onMouseOut="MM_swapImgRestore()" onMouseOver="MM_swapImage('ePrints_banner_r6_c4','','/images/eprints/ePrints_banner_r6_c4_f2.gif',1);"><img name="ePrints_banner_r6_c4" src="/images/eprints/ePrints_banner_r6_c4.gif" width="105" height="24" border="0" alt="ePrints home" /></a></td>
<td><img src="/images/eprints/spacer.gif" width="1" height="24" border="0" alt="" /></td>
</tr>
<tr>
<td><img name="ePrints_banner_r7_c2" src="/images/eprints/ePrints_banner_r7_c2.gif" width="104" height="15" border="0" alt="" /></td>
<td colspan="8"><img name="ePrints_banner_r7_c4" src="/images/eprints/ePrints_banner_r7_c4.gif" width="517" height="15" border="0" alt="" /></td>
<td><img src="/images/eprints/spacer.gif" width="1" height="15" border="0" alt="" /></td>
</tr>
</table></td>
</tr>
<tr><td><table width="100%" style="font-size: 90%; border: solid 1px #ccc; padding: 3px"><tr>
<td align="left"><a href="http://eprints.utas.edu.au/cgi/users/home">Login</a> | <a href="http://eprints.utas.edu.au/cgi/register">Create Account</a></td>
<td align="right" style="white-space: nowrap">
<form method="get" accept-charset="utf-8" action="http://eprints.utas.edu.au/cgi/search" style="display:inline">
<input class="ep_tm_searchbarbox" size="20" type="text" name="q" />
<input class="ep_tm_searchbarbutton" value="Search" type="submit" name="_action_search" />
<input type="hidden" name="_order" value="bytitle" />
<input type="hidden" name="basic_srchtype" value="ALL" />
<input type="hidden" name="_satisfyall" value="ALL" />
</form>
</td>
</tr></table></td></tr>
<tr>
<td class="toplinks"><!-- InstanceBeginEditable name="content" -->
<div align="center">
<table width="720" class="ep_tm_main"><tr><td align="left">
<h1 class="ep_tm_pagetitle">Detection and mapping of QTL on bovine chromosomes 2 and 5 segregating for live weight, average daily gain and body measurements in Japanese Black Cattle</h1>
<p style="margin-bottom: 1em" class="not_ep_block"><span class="person_name">Malau-Aduli, A.E.O.</span> and <span class="person_name">Niibayashi, T.</span> and <span class="person_name">Kojima, T.</span> and <span class="person_name">Oshima, K.</span> and <span class="person_name">Mizoguchi, Y.</span> and <span class="person_name">Komatsu, M.</span> (2007) <xhtml:em>Detection and mapping of QTL on bovine chromosomes 2 and 5 segregating for live weight, average daily gain and body measurements in Japanese Black Cattle.</xhtml:em> Journal of Cell and Animal Biology, 1 (3). pp. 034-043. ISSN 1996-0867</p><p style="margin-bottom: 1em" class="not_ep_block"></p><table style="margin-bottom: 1em" class="not_ep_block"><tr><td valign="top" style="text-align:center"><a onmouseover="EPJS_ShowPreview( event, 'doc_preview_4231' );" href="http://eprints.utas.edu.au/3083/2/Malau-Adulietal2007JCAB.pdf" onmouseout="EPJS_HidePreview( event, 'doc_preview_4231' );"><img alt="[img]" src="http://eprints.utas.edu.au/style/images/fileicons/application_pdf.png" class="ep_doc_icon" border="0" /></a><div class="ep_preview" id="doc_preview_4231"><table><tr><td><img alt="" src="http://eprints.utas.edu.au/3083/thumbnails/2/preview.png" class="ep_preview_image" border="0" /><div class="ep_preview_title">Preview</div></td></tr></table></div></td><td valign="top"><a href="http://eprints.utas.edu.au/3083/2/Malau-Adulietal2007JCAB.pdf"><span class="ep_document_citation">PDF</span></a> - Requires a PDF viewer<br />205Kb</td></tr></table><p style="margin-bottom: 1em" class="not_ep_block">Official URL: <a href="http://www.academicjournals.org/JCAB/contents/2007cont/Oct.htm">http://www.academicjournals.org/JCAB/contents/2007cont/Oct.htm</a></p><div class="not_ep_block"><h2>Abstract</h2><p style="padding-bottom: 16px; text-align: left; margin: 1em auto 0em auto">Bovine chromosomes 2 (BTA2) and 5 (BTA5) of purebred, half-sib progeny sired by five Japanese black
bulls were genotyped using microsatellite DNA markers. The data were subjected to linkage analysis for
the detection and mapping of segregating quantitative trait loci (QTL) influencing live weight, average
daily gain and body measurements at weaning. Probability coefficients of inheriting allele 1 or 2 from the
sire at specific chromosomal intervals were computed. The phenotypic data on progeny were regressed on
these probability coefficients in a within-common-parent regression analysis. Fixed effects of sex, parity
and season of birth as well as age as a covariate, were fitted in a linear model to the phenotypic data and
subsequently analysed using QTL Express by generating an F-statistic through permutation tests at
chromosome-wide significance thresholds over 10, 000 iterations at 1 cM intervals. Highly significant
(P<0.01) segregating QTL for body measurements were detected on BTA2 for hip width (1 cM) and chest
depth (8 cM) in Sire Family 1 and pin bone width (16 cM) in Sire Family 3. Other significant QTL (P<0.05)
detected were withers height (3 cM), hip height (4 cM), body length (4 cM), shoulder width (6 cM), lumbar
width (3 cM), thurl width (3 cM) and canon circumference (2 cM) in Sire Family 1, shoulder width (16 cM) in
Sire Family 3 and thurl width (24 cM), pin bone width (19 cM), heart girth (26 cM) and abdominal width (69
cM) in Sire Family 4. Significant (P<0.05) QTL for live weight and average daily gain were detected on BTA2
for birth weight (5 cM) and weaning weight (3 cM) in Sire Family 1 and post-weaning average daily gain (68
cM) in Sire Family 4. BTA 5 contained QTL for birth weight, pin bone width and heart girth in Sire Family 3
that were only suggestive and not significant. Such localization of economically important QTL as
demonstrated in this study, will expedite genetic improvement via marker-assisted selection, gene
introgression and positional cloning in Japanese black cattle.</p></div><table style="margin-bottom: 1em" cellpadding="3" class="not_ep_block" border="0"><tr><th valign="top" class="ep_row">Item Type:</th><td valign="top" class="ep_row">Article</td></tr><tr><th valign="top" class="ep_row">Keywords:</th><td valign="top" class="ep_row">QTL mapping, Japanese Black cattle, BTA2, BTA5, body measurements, live weight, daily gain.</td></tr><tr><th valign="top" class="ep_row">Subjects:</th><td valign="top" class="ep_row"><a href="http://eprints.utas.edu.au/view/subjects/270200.html">270000 Biological Sciences > 270200 Genetics</a><br /><a href="http://eprints.utas.edu.au/view/subjects/270207.html">270000 Biological Sciences > 270200 Genetics > 270207 Quantitative Genetics</a><br /><a href="http://eprints.utas.edu.au/view/subjects/300401.html">300000 Agricultural, Veterinary and Environmental Sciences > 300400 Animal Production > 300401 Animal Breeding</a><br /><a href="http://eprints.utas.edu.au/view/subjects/270208.html">270000 Biological Sciences > 270200 Genetics > 270208 Molecular Evolution</a><br /><a href="http://eprints.utas.edu.au/view/subjects/300406.html">300000 Agricultural, Veterinary and Environmental Sciences > 300400 Animal Production > 300406 Animal Growth and Development</a><br /><a href="http://eprints.utas.edu.au/view/subjects/300400.html">300000 Agricultural, Veterinary and Environmental Sciences > 300400 Animal Production</a><br /><a href="http://eprints.utas.edu.au/view/subjects/270800.html">270000 Biological Sciences > 270800 Biotechnology</a></td></tr><tr><th valign="top" class="ep_row">Collections:</th><td valign="top" class="ep_row">UNSPECIFIED</td></tr><tr><th valign="top" class="ep_row">ID Code:</th><td valign="top" class="ep_row">3083</td></tr><tr><th valign="top" class="ep_row">Deposited By:</th><td valign="top" class="ep_row"><span class="ep_name_citation"><span class="person_name">Dr Aduli E.O. Malau-Aduli</span></span></td></tr><tr><th valign="top" class="ep_row">Deposited On:</th><td valign="top" class="ep_row">23 Jan 2008 13:45</td></tr><tr><th valign="top" class="ep_row">Last Modified:</th><td valign="top" class="ep_row">24 Jan 2008 11:02</td></tr><tr><th valign="top" class="ep_row">ePrint Statistics:</th><td valign="top" class="ep_row"><a target="ePrintStats" href="/es/index.php?action=show_detail_eprint;id=3083;">View statistics for this ePrint</a></td></tr></table><p align="right">Repository Staff Only: <a href="http://eprints.utas.edu.au/cgi/users/home?screen=EPrint::View&eprintid=3083">item control page</a></p>
</td></tr></table>
</div>
<!-- InstanceEndEditable --></td>
</tr>
<tr>
<td><!-- #BeginLibraryItem "/Library/footer_eprints.lbi" -->
<table width="795" border="0" align="left" cellpadding="0" class="footer">
<tr valign="top">
<td colspan="2"><div align="center"><a href="http://www.utas.edu.au">UTAS home</a> | <a href="http://www.utas.edu.au/library/">Library home</a> | <a href="/">ePrints home</a> | <a href="/contact.html">contact</a> | <a href="/information.html">about</a> | <a href="/view/">browse</a> | <a href="/perl/search/simple">search</a> | <a href="/perl/register">register</a> | <a href="/perl/users/home">user area</a> | <a href="/help/">help</a></div><br /></td>
</tr>
<tr><td colspan="2"><p><img src="/images/eprints/footerline.gif" width="100%" height="4" /></p></td></tr>
<tr valign="top">
<td width="68%" class="footer">Authorised by the University Librarian<br />
© University of Tasmania ABN 30 764 374 782<br />
<a href="http://www.utas.edu.au/cricos/">CRICOS Provider Code 00586B</a> | <a href="http://www.utas.edu.au/copyright/copyright_disclaimers.html">Copyright & Disclaimers</a> | <a href="http://www.utas.edu.au/accessibility/index.html">Accessibility</a> | <a href="http://eprints.utas.edu.au/feedback/">Site Feedback</a> </td>
<td width="32%"><div align="right">
<p align="right" class="NoPrint"><a href="http://www.utas.edu.au/"><img src="http://www.utas.edu.au/shared/logos/unioftasstrip.gif" alt="University of Tasmania Home Page" width="260" height="16" border="0" align="right" /></a></p>
<p align="right" class="NoPrint"><a href="http://www.utas.edu.au/"><br />
</a></p>
</div></td>
</tr>
<tr valign="top">
<td><p> </p></td>
<td><div align="right"><span class="NoPrint"><a href="http://www.eprints.org/software/"><img src="/images/eprintslogo.gif" alt="ePrints logo" width="77" height="29" border="0" align="bottom" /></a></span></div></td>
</tr>
</table>
<!-- #EndLibraryItem -->
<div align="center"></div></td>
</tr>
</table>
</body>
</html>
