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<title>UTas ePrints - Does adrenal responsiveness vary with sex and reproductive status in Egernia whitii, a viviparous skink?</title>
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<meta content="Cartledge, Victoria A." name="eprints.creators_name" />
<meta content="Jones, Susan M." name="eprints.creators_name" />
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<meta content="S.M.Jones@utas.edu.au" name="eprints.creators_id" />
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<meta content="2007-02-14" name="eprints.datestamp" />
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<meta content="Does adrenal responsiveness vary with sex and reproductive status in Egernia whitii, a viviparous skink?" name="eprints.title" />
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<meta content="ACTH; capture; corticosterone; oestrogen; reptile; stress; viviparity" name="eprints.keywords" />
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<meta content="In mammals, oestrogens generally stimulate adrenal function whilst androgens are inhibitory, and gestating females down-regulate their acute response to stressors in order to protect current reproductive investment. This study aimed to determine if adrenocortical function is similarly modulated by sex and reproductive status in the viviparous lizard, Egernia whitii. We compared the adrenocortical response to acute capture stress in female E. whitii during active (post-ovulatory and gestating) and quiescent (post-partum) phases of their reproductive cycle. We also compared the responses of reproductively quiescent males and females to acute stress and ACTH challenge to determine if there are sex-related differences in HPA axis activity when the influence of reproductive hormones is minimal. The females' responses to acute capture stress varied significantly with reproductive stage, and quiescent females displayed the strongest immediate response, with a rapid and sustained increase in plasma corticosterone (CORT) concentrations. Post-ovulatory females showed the most conservative adrenocortical response and while gestating females showed a large immediate response, this was not as prolonged Lis in quiescent females. Reproductively quiescent males and females exhibited similar responses to acute stress, and also responded similarly to ACTH injection, with plasma CORT reaching maximal concentrations of 52.1 and 59.4ng/mL, respectively. Reproductively quiescent females treated with oestrogen exhibited greater responsiveness to ACTH than control females, although basal plasma CORT concentrations were unaltered: these results suggest that the attenuation of the acute stress response observed in reproductively active females of E. whitii may be regulated upstream of ACTH secretion. Our results demonstrate that the activity of the HPA axis is modulated by reproductive status in this viviparous reptile, and that gestating females are able to buffer their embryos from the potentially adverse effects of elevated plasma corticosteroids. " name="eprints.abstract" />
<meta content="2007-01" name="eprints.date" />
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<meta content="General and Comparative Endocrinology" name="eprints.publication" />
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<meta content="132-139" name="eprints.pagerange" />
<meta content="10.1016/j.ygcen.2006.07.021" name="eprints.id_number" />
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<meta content="Astheimer, L. B., Buttemer, W. A. and Wingfield, J. C. (1995). Seasonal and acute changes in adrenocortical responsiveness in an Arctic-breeding bird. Horm. Behav. 29, 442-457.
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<meta content="In mammals, oestrogens generally stimulate adrenal function whilst androgens are inhibitory, and gestating females down-regulate their acute response to stressors in order to protect current reproductive investment. This study aimed to determine if adrenocortical function is similarly modulated by sex and reproductive status in the viviparous lizard, Egernia whitii. We compared the adrenocortical response to acute capture stress in female E. whitii during active (post-ovulatory and gestating) and quiescent (post-partum) phases of their reproductive cycle. We also compared the responses of reproductively quiescent males and females to acute stress and ACTH challenge to determine if there are sex-related differences in HPA axis activity when the influence of reproductive hormones is minimal. The females' responses to acute capture stress varied significantly with reproductive stage, and quiescent females displayed the strongest immediate response, with a rapid and sustained increase in plasma corticosterone (CORT) concentrations. Post-ovulatory females showed the most conservative adrenocortical response and while gestating females showed a large immediate response, this was not as prolonged Lis in quiescent females. Reproductively quiescent males and females exhibited similar responses to acute stress, and also responded similarly to ACTH injection, with plasma CORT reaching maximal concentrations of 52.1 and 59.4ng/mL, respectively. Reproductively quiescent females treated with oestrogen exhibited greater responsiveness to ACTH than control females, although basal plasma CORT concentrations were unaltered: these results suggest that the attenuation of the acute stress response observed in reproductively active females of E. whitii may be regulated upstream of ACTH secretion. Our results demonstrate that the activity of the HPA axis is modulated by reproductive status in this viviparous reptile, and that gestating females are able to buffer their embryos from the potentially adverse effects of elevated plasma corticosteroids. " name="DC.description" />
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<h1 class="ep_tm_pagetitle">Does adrenal responsiveness vary with sex and reproductive status in Egernia whitii, a viviparous skink?</h1>
<p style="margin-bottom: 1em" class="not_ep_block"><span class="person_name">Cartledge, Victoria A.</span> and <span class="person_name">Jones, Susan M.</span> (2007) <xhtml:em>Does adrenal responsiveness vary with sex and reproductive status in Egernia whitii, a viviparous skink?</xhtml:em> General and Comparative Endocrinology, 150 (1). pp. 132-139. ISSN 0016-6480</p><p style="margin-bottom: 1em" class="not_ep_block"></p><table style="margin-bottom: 1em" class="not_ep_block"><tr><td valign="top" style="text-align:center"><a href="http://eprints.utas.edu.au/743/1/VC_female.pdf"><img alt="[img]" src="http://eprints.utas.edu.au/style/images/fileicons/application_pdf.png" border="0" class="ep_doc_icon" /></a></td><td valign="top"><a href="http://eprints.utas.edu.au/743/1/VC_female.pdf"><span class="ep_document_citation">PDF</span></a> - Full text restricted - Requires a PDF viewer<br />316Kb</td><td><form method="get" accept-charset="utf-8" action="http://eprints.utas.edu.au/cgi/request_doc"><input value="751" name="docid" accept-charset="utf-8" type="hidden" /><div class=""><input value="Request a copy" name="_action_null" class="ep_form_action_button" onclick="return EPJS_button_pushed( '_action_null' )" type="submit" /> </div></form></td></tr><tr><td valign="top" style="text-align:center"><a onmouseover="EPJS_ShowPreview( event, 'doc_preview_752' );" onmouseout="EPJS_HidePreview( event, 'doc_preview_752' );" href="http://eprints.utas.edu.au/743/2/Cartledge__Jones_postreview_23_05_06.pdf"><img alt="[img]" src="http://eprints.utas.edu.au/style/images/fileicons/application_pdf.png" border="0" class="ep_doc_icon" /></a><div class="ep_preview" id="doc_preview_752"><table><tr><td><img alt="" src="http://eprints.utas.edu.au/743/thumbnails/2/preview.png" border="0" class="ep_preview_image" /><div class="ep_preview_title">Preview</div></td></tr></table></div></td><td valign="top"><a href="http://eprints.utas.edu.au/743/2/Cartledge__Jones_postreview_23_05_06.pdf"><span class="ep_document_citation">PDF (Author Version)</span></a> - Requires a PDF viewer<br />115Kb</td></tr></table><p style="margin-bottom: 1em" class="not_ep_block">Official URL: <a href="http://dx.doi.org/10.1016/j.ygcen.2006.07.021">http://dx.doi.org/10.1016/j.ygcen.2006.07.021</a></p><div class="not_ep_block"><h2>Abstract</h2><p style="padding-bottom: 16px; text-align: left; margin: 1em auto 0em auto">In mammals, oestrogens generally stimulate adrenal function whilst androgens are inhibitory, and gestating females down-regulate their acute response to stressors in order to protect current reproductive investment. This study aimed to determine if adrenocortical function is similarly modulated by sex and reproductive status in the viviparous lizard, Egernia whitii. We compared the adrenocortical response to acute capture stress in female E. whitii during active (post-ovulatory and gestating) and quiescent (post-partum) phases of their reproductive cycle. We also compared the responses of reproductively quiescent males and females to acute stress and ACTH challenge to determine if there are sex-related differences in HPA axis activity when the influence of reproductive hormones is minimal. The females' responses to acute capture stress varied significantly with reproductive stage, and quiescent females displayed the strongest immediate response, with a rapid and sustained increase in plasma corticosterone (CORT) concentrations. Post-ovulatory females showed the most conservative adrenocortical response and while gestating females showed a large immediate response, this was not as prolonged Lis in quiescent females. Reproductively quiescent males and females exhibited similar responses to acute stress, and also responded similarly to ACTH injection, with plasma CORT reaching maximal concentrations of 52.1 and 59.4ng/mL, respectively. Reproductively quiescent females treated with oestrogen exhibited greater responsiveness to ACTH than control females, although basal plasma CORT concentrations were unaltered: these results suggest that the attenuation of the acute stress response observed in reproductively active females of E. whitii may be regulated upstream of ACTH secretion. Our results demonstrate that the activity of the HPA axis is modulated by reproductive status in this viviparous reptile, and that gestating females are able to buffer their embryos from the potentially adverse effects of elevated plasma corticosteroids. </p></div><table style="margin-bottom: 1em" border="0" cellpadding="3" class="not_ep_block"><tr><th valign="top" class="ep_row">Item Type:</th><td valign="top" class="ep_row">Article</td></tr><tr><th valign="top" class="ep_row">Additional Information:</th><td valign="top" class="ep_row">http://www.elsevier.com/locate/ygcen</td></tr><tr><th valign="top" class="ep_row">Keywords:</th><td valign="top" class="ep_row">ACTH; capture; corticosterone; oestrogen; reptile; stress; viviparity</td></tr><tr><th valign="top" class="ep_row">Subjects:</th><td valign="top" class="ep_row"><a href="http://eprints.utas.edu.au/view/subjects/270604.html">270000 Biological Sciences > 270600 Physiology > 270604 Comparative Physiology</a></td></tr><tr><th valign="top" class="ep_row">Collections:</th><td valign="top" class="ep_row">UNSPECIFIED</td></tr><tr><th valign="top" class="ep_row">ID Code:</th><td valign="top" class="ep_row">743</td></tr><tr><th valign="top" class="ep_row">Deposited By:</th><td valign="top" class="ep_row"><span class="ep_name_citation"><span class="person_name">A/Prof. Susan M. Jones</span></span></td></tr><tr><th valign="top" class="ep_row">Deposited On:</th><td valign="top" class="ep_row">14 Feb 2007</td></tr><tr><th valign="top" class="ep_row">Last Modified:</th><td valign="top" class="ep_row">04 Feb 2008 13:08</td></tr><tr><th valign="top" class="ep_row">ePrint Statistics:</th><td valign="top" class="ep_row"><a target="ePrintStats" href="/es/index.php?action=show_detail_eprint;id=743;">View statistics for this ePrint</a></td></tr></table><p align="right">Repository Staff Only: <a href="http://eprints.utas.edu.au/cgi/users/home?screen=EPrint::View&eprintid=743">item control page</a></p>
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