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<title>UTas ePrints - Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdown</title>
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<meta content="Ding, Changhai" name="eprints.creators_name" />
<meta content="Garnero, Patrick" name="eprints.creators_name" />
<meta content="Cicuttini, Flavia" name="eprints.creators_name" />
<meta content="Scott, Fiona" name="eprints.creators_name" />
<meta content="Cooley, Helen" name="eprints.creators_name" />
<meta content="Jones, Graeme" name="eprints.creators_name" />
<meta content="chding@utas.edu.au" name="eprints.creators_id" />
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<meta content="Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdown" name="eprints.title" />
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<meta content="Knee; Cartilage defects; Osteoarthritis; Volume; Bone area; Type II collagen " name="eprints.keywords" />
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<meta content="Objective:
To generate hypotheses regarding the associations between knee cartilage defects and knee radiographic osteoarthritis (ROA), cartilage volume, bone size and type II collagen breakdown in adults.
Methods:
A cross-sectional convenience sample of 372 male and female subjects (mean age 45 years, range 26-61) was studied. Knee cartilage defect score (0-4) and prevalence (a defect score of >=2), cartilage volume, and bone surface area were determined using T1-weighted fat saturation MRI. Urinary levels of C-terminal crosslinking telopeptide of type II collagen (U-CTX-II) were measured by enzyme-linked immunosorbent assay. Height, weight and ROA were measured by standard protocols.
Results:
In multivariate analysis, the severity and prevalence of knee cartilage defects were significantly and independently associated with tibiofemoral osteophytes (regression coefficient (beta): +0.86 to +1.31/unit, odds ratio (OR): 2.97-3.68/unit, all P < 0.05 with the exception of OR in lateral tibiofemoral compartment) and tibial bone area (beta: +0.11 to +0.25/cm2; OR: 1.33-1.58/cm2, all P < 0.01). Knee cartilage defects were inconsistently associated with joint space narrowing after adjustment for osteophytes but consistently with knee cartilage volume (beta: -0.27 to -0.70/ml; OR: 0.16-0.56/ml, all P < 0.01 except for OR at lateral tibial cartilage site P = 0.06). Lastly, knee cartilage defect severity was significantly associated with U-CTX-II (Partial r = +0.18, P < 0.001 for total cartilage defect score).
Conclusion:
Osteophytes and increasing knee bone size may be causally related to knee cartilage defects. Furthermore, knee cartilage defects may result in increased cartilage breakdown leading to decreased cartilage volume and joint space narrowing suggesting an important role for knee cartilage defects in early knee OA.
" name="eprints.abstract" />
<meta content="2005-03-01" name="eprints.date" />
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<meta content="Osteoarthritis and Cartilage" name="eprints.publication" />
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<meta content="Ding, Changhai and Garnero, Patrick and Cicuttini, Flavia and Scott, Fiona and Cooley, Helen and Jones, Graeme (2005) Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdown. Osteoarthritis and Cartilage, 13 (3). pp. 198-205. ISSN 1063-4584" name="eprints.citation" />
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<meta content="Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdown" name="DC.title" />
<meta content="Ding, Changhai" name="DC.creator" />
<meta content="Garnero, Patrick" name="DC.creator" />
<meta content="Cicuttini, Flavia" name="DC.creator" />
<meta content="Scott, Fiona" name="DC.creator" />
<meta content="Cooley, Helen" name="DC.creator" />
<meta content="Jones, Graeme" name="DC.creator" />
<meta content="321028 Rheumatology and Arthritis" name="DC.subject" />
<meta content="Objective:
To generate hypotheses regarding the associations between knee cartilage defects and knee radiographic osteoarthritis (ROA), cartilage volume, bone size and type II collagen breakdown in adults.
Methods:
A cross-sectional convenience sample of 372 male and female subjects (mean age 45 years, range 26-61) was studied. Knee cartilage defect score (0-4) and prevalence (a defect score of >=2), cartilage volume, and bone surface area were determined using T1-weighted fat saturation MRI. Urinary levels of C-terminal crosslinking telopeptide of type II collagen (U-CTX-II) were measured by enzyme-linked immunosorbent assay. Height, weight and ROA were measured by standard protocols.
Results:
In multivariate analysis, the severity and prevalence of knee cartilage defects were significantly and independently associated with tibiofemoral osteophytes (regression coefficient (beta): +0.86 to +1.31/unit, odds ratio (OR): 2.97-3.68/unit, all P < 0.05 with the exception of OR in lateral tibiofemoral compartment) and tibial bone area (beta: +0.11 to +0.25/cm2; OR: 1.33-1.58/cm2, all P < 0.01). Knee cartilage defects were inconsistently associated with joint space narrowing after adjustment for osteophytes but consistently with knee cartilage volume (beta: -0.27 to -0.70/ml; OR: 0.16-0.56/ml, all P < 0.01 except for OR at lateral tibial cartilage site P = 0.06). Lastly, knee cartilage defect severity was significantly associated with U-CTX-II (Partial r = +0.18, P < 0.001 for total cartilage defect score).
Conclusion:
Osteophytes and increasing knee bone size may be causally related to knee cartilage defects. Furthermore, knee cartilage defects may result in increased cartilage breakdown leading to decreased cartilage volume and joint space narrowing suggesting an important role for knee cartilage defects in early knee OA.
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<h1 class="ep_tm_pagetitle">Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdown</h1>
<p style="margin-bottom: 1em" class="not_ep_block"><span class="person_name">Ding, Changhai</span> and <span class="person_name">Garnero, Patrick</span> and <span class="person_name">Cicuttini, Flavia</span> and <span class="person_name">Scott, Fiona</span> and <span class="person_name">Cooley, Helen</span> and <span class="person_name">Jones, Graeme</span> (2005) <xhtml:em>Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdown.</xhtml:em> Osteoarthritis and Cartilage, 13 (3). pp. 198-205. ISSN 1063-4584</p><p style="margin-bottom: 1em" class="not_ep_block"></p><table style="margin-bottom: 1em" class="not_ep_block"><tr><td valign="top" style="text-align:center"><a href="http://eprints.utas.edu.au/940/1/O_%26_C_paper.pdf"><img alt="[img]" src="http://eprints.utas.edu.au/style/images/fileicons/application_pdf.png" class="ep_doc_icon" border="0" /></a></td><td valign="top"><a href="http://eprints.utas.edu.au/940/1/O_%26_C_paper.pdf"><span class="ep_document_citation">PDF</span></a> - Full text restricted - Requires a PDF viewer<br />438Kb</td></tr></table><p style="margin-bottom: 1em" class="not_ep_block">Official URL: <a href="http://dx.doi.org/10.1016/j.joca.2004.11.007">http://dx.doi.org/10.1016/j.joca.2004.11.007</a></p><div class="not_ep_block"><h2>Abstract</h2><p style="padding-bottom: 16px; text-align: left; margin: 1em auto 0em auto">Objective:
To generate hypotheses regarding the associations between knee cartilage defects and knee radiographic osteoarthritis (ROA), cartilage volume, bone size and type II collagen breakdown in adults.
Methods:
A cross-sectional convenience sample of 372 male and female subjects (mean age 45 years, range 26-61) was studied. Knee cartilage defect score (0-4) and prevalence (a defect score of >=2), cartilage volume, and bone surface area were determined using T1-weighted fat saturation MRI. Urinary levels of C-terminal crosslinking telopeptide of type II collagen (U-CTX-II) were measured by enzyme-linked immunosorbent assay. Height, weight and ROA were measured by standard protocols.
Results:
In multivariate analysis, the severity and prevalence of knee cartilage defects were significantly and independently associated with tibiofemoral osteophytes (regression coefficient (beta): +0.86 to +1.31/unit, odds ratio (OR): 2.97-3.68/unit, all P < 0.05 with the exception of OR in lateral tibiofemoral compartment) and tibial bone area (beta: +0.11 to +0.25/cm2; OR: 1.33-1.58/cm2, all P < 0.01). Knee cartilage defects were inconsistently associated with joint space narrowing after adjustment for osteophytes but consistently with knee cartilage volume (beta: -0.27 to -0.70/ml; OR: 0.16-0.56/ml, all P < 0.01 except for OR at lateral tibial cartilage site P = 0.06). Lastly, knee cartilage defect severity was significantly associated with U-CTX-II (Partial r = +0.18, P < 0.001 for total cartilage defect score).
Conclusion:
Osteophytes and increasing knee bone size may be causally related to knee cartilage defects. Furthermore, knee cartilage defects may result in increased cartilage breakdown leading to decreased cartilage volume and joint space narrowing suggesting an important role for knee cartilage defects in early knee OA.
</p></div><table style="margin-bottom: 1em" cellpadding="3" class="not_ep_block" border="0"><tr><th valign="top" class="ep_row">Item Type:</th><td valign="top" class="ep_row">Article</td></tr><tr><th valign="top" class="ep_row">Additional Information:</th><td valign="top" class="ep_row">Definitive version available online at: http://www.sciencedirect.com/</td></tr><tr><th valign="top" class="ep_row">Keywords:</th><td valign="top" class="ep_row">Knee; Cartilage defects; Osteoarthritis; Volume; Bone area; Type II collagen </td></tr><tr><th valign="top" class="ep_row">Subjects:</th><td valign="top" class="ep_row"><a href="http://eprints.utas.edu.au/view/subjects/321028.html">320000 Medical and Health Sciences > 321000 Clinical Sciences > 321028 Rheumatology and Arthritis</a></td></tr><tr><th valign="top" class="ep_row">ID Code:</th><td valign="top" class="ep_row">940</td></tr><tr><th valign="top" class="ep_row">Deposited By:</th><td valign="top" class="ep_row"><span class="ep_name_citation"><span class="person_name">Dr Changhai / C Ding</span></span></td></tr><tr><th valign="top" class="ep_row">Deposited On:</th><td valign="top" class="ep_row">03 May 2007</td></tr><tr><th valign="top" class="ep_row">Last Modified:</th><td valign="top" class="ep_row">09 Jan 2008 02:30</td></tr><tr><th valign="top" class="ep_row">ePrint Statistics:</th><td valign="top" class="ep_row"><a target="ePrintStats" href="/es/index.php?action=show_detail_eprint;id=940;">View statistics for this ePrint</a></td></tr></table><p align="right">Repository Staff Only: <a href="http://eprints.utas.edu.au/cgi/users/home?screen=EPrint::View&eprintid=940">item control page</a></p>
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